Association of Chinese visceral adiposity index with clinical outcome in patients after endovascular thrombectomy

• Published in: Journal of stroke and cerebrovascular diseases 2024-01, Vol.33 (1), p.107464-107464, Article 107464
• Main Authors: Xu, Lili, Chen, Shuaiyu, Xu, Jing, Shi, Yanyan, Huang, Zhihang, Wang, Meng, Wei, Ziqiao, Cao, Hui, Zhou, Junshan, Wang, Wei, Du, Mingyang
• Format: Article
• Language: English
• Subjects: Adiposity; Aged; Aged, 80 and over; Endovascular Procedures - adverse effects; Humans; Ischemic Stroke - etiology; Male; Middle Aged; Retrospective Studies; Stroke - diagnostic imaging; Stroke - therapy; Thrombectomy - adverse effects; Treatment Outcome
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2023.107464

The Chinese Visceral Adiposity Index (CVAI) is a reliable indicator of visceral adiposity dysfunction in the Chinese population. We aimed to evaluate the association between CVAI and clinical outcome in Chinese ischemic stroke patients who received endovascular thrombectomy (EVT). This study retrospectively included patients with large vessel occlusive stroke receiving EVT treatment in 2 China stroke centers. Baseline CVAI was calculated after admission. Patients with a modified Rankin scale score ≥ 3 at 3 months after ischemic stroke were defined as poor outcome. Binary multivariate logistic regression models were utilized to explore the association between CVAI and the risk of 90-day unfavorable outcome. A total of 453 patients (mean age, 70.4  ± 12.1 years; 280 male) were included. During the 90-day follow-up, 236 (52.1 %) patients experienced poor outcome. After multivariable adjustment for potential confounders, increasing CVAI was associated with an increased risk of 90-day poor outcome (odds ratios, per-standard deviation increase: 1.521; 95 % confidence interval, 1.127-2.052; P = 0.006). Similar significant results were observed when the CVAI was analyzed as a categorical variable. Furthermore, the multiple-adjusted spline regression model showed an inverted J-shape association between CVAI and risk of unfavorable outcome (P = 0.048 for non-linearity). This study demonstrated that CVAI is positively correlated with 90-day poor outcome in Chinese ischemic stroke patients after EVT.