Prognostic potential of circulating cell free mitochondrial DNA levels in COVID-19 patients

Background In viral infections, mitochondria act as one of the main hubs of the pathogenesis. Recent findings present new insights into the potential role of circulating cell-free mitochondrial DNA (ccf-mtDNA) in COVID-19 pathogenesis by the induction of immune response and aggressive cytokine storm...

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Published in:Molecular biology reports 2023-12, Vol.50 (12), p.10249-10255
Main Authors: Mahmoodpoor, Ata, Mohammadzadeh, Mojtaba, Asghari, Rogayyeh, Tagizadeh, Majid, Iranpour, Afshin, Rezayi, Mansour, Pahnvar, Aynour Jalali, Emamalizadeh, Babak, Sohrabifar, Nasim, Kazeminasab, Somayeh
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Cardiovascular disease
Cell-Free Nucleic Acids - genetics
Comorbidity
COVID-19
COVID-19 - genetics
Cytokine storm
DNA, Mitochondrial - genetics
Histology
Humans
Immune response
Life Sciences
Mitochondria - genetics
Mitochondrial DNA
Morphology
Mortality
Original Article
Pathogenesis
Polymerase chain reaction
Prognosis
Risk factors
SARS-CoV-2 - genetics
Severe acute respiratory syndrome coronavirus 2
Statistical analysis
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Summary:Background In viral infections, mitochondria act as one of the main hubs of the pathogenesis. Recent findings present new insights into the potential role of circulating cell-free mitochondrial DNA (ccf-mtDNA) in COVID-19 pathogenesis by the induction of immune response and aggressive cytokine storm in SARS-CoV-2 infection. Methods and results The levels of ccf-mtDNA were investigated in 102 hospitalized patients with COVID-19 using the quantitative PCR (q-PCR) method. Statistical analysis confirmed a strong association between the levels of ccf-mtDNA and and mortality, ICU admission, and intubation. Also, our findings highlighted the pivotal role of comorbidities as a risk factor for COVID-19 mortality and severity. Conclusion Higher levels of ccf-mtDNA can serve as a potential early indicator for progress and poor prognosis of COVID-19.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-023-08841-3