Potential of milk-derived bioactive peptides as antidiabetic, antihypertensive, and xanthine oxidase inhibitors: a comprehensive bibliometric analysis and updated review

Bioactive peptides consist of small protein fragments, which are inactive in their original conformation, and they become active when released from these through enzymatic hydrolysis or fermentation processes. The bioactivity of such peptides has been extensively reported in the literature as contri...

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Bibliographic Details
Published in:Amino acids 2023-12, Vol.55 (12), p.1829-1855
Main Authors: Bellaver, Emyr Hiago, Kempka, Aniela Pinto
Format: Article
Language:English
Subjects:
Analytical Chemistry
Antidiabetics
Antihypertensives
Bibliometrics
Biochemical Engineering
Biochemistry
Biological activity
Biomedical and Life Sciences
Dairy products
Diabetes mellitus
Fermentation
Homeostasis
Hydrophobicity
Immunomodulation
Life Sciences
Literature reviews
Low molecular weights
Milk
Molecular interactions
Molecular weight
Neurobiology
Peptides
Proteomics
Review Article
Uric acid
Xanthine oxidase
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Summary:Bioactive peptides consist of small protein fragments, which are inactive in their original conformation, and they become active when released from these through enzymatic hydrolysis or fermentation processes. The bioactivity of such peptides has been extensively reported in the literature as contributors to organic homeostasis processes, as well as in immunomodulation, organism defense against oxidative processes, among others. In this study, reports of the activity of BPs isolated from milk with the potential glycemic control, antihypertensive activity, and inhibitors of uric acid formation were compiled. A systematic literature review and bibliometric analysis were conducted, using the PICO strategy for the research. The temporal analysis of publications revealed a growing interest in the investigation of bioactive peptides with potential antidiabetic, antihypertensive, and xanthine oxidase inhibitory activities, using dairy sources as products for their extraction. The literature analysis also revealed an increase in research involving non-bovine dairy products for bioactive peptide extraction. The collaboration network among authors exhibited weaknesses in scientific cooperation. Regarding the analysis of keywords, the usage of terms such as “bioactive peptides”, “antioxidant”, “antihypertensive”, and “diabetes” was evident, constituting the main research clusters. Peptides with low molecular weight, typically 
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-023-03351-9