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Polypharmacy in antipsychotic pharmacological treatment among patients with dual diagnosis in Denmark
Antipsychotic polypharmacy is prevalent, however literature on antipsychotic polypharmacy during treatment among patients with dual diagnosis is largely non-existent. This study aims to investigating the extent of antipsychotic polypharmacy dual diagnosis patients during hospitalisations. Utilizing...
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Published in: | Nordic journal of psychiatry 2024-02, Vol.78 (2), p.112-119 |
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creator | Jobe, Lei Blandin Mårtensson, Solvej Düring, Signe Wegmann |
description | Antipsychotic polypharmacy is prevalent, however literature on antipsychotic polypharmacy during treatment among patients with dual diagnosis is largely non-existent. This study aims to investigating the extent of antipsychotic polypharmacy dual diagnosis patients during hospitalisations.
Utilizing cohort data from an integrated dual diagnosis in-patient facility from patients hospitalized between 1 March 2012, to 31 December 2016, we compared the mean antipsychotic medication administered at admission and discharge and examined covariate associations with logistic regressions.
The study identified 907 hospital admissions, of which 641 were the first for each patient during the period. At admission, 74.1% received antipsychotics; polypharmacy spanned psychiatric disorders. categories. Patients with affective or personality spectrum disorders were less likely to have antipsychotic polypharmacy upon admission compared to those with psychosis spectrum disorders. 2013-2016 admissions presented less polypharmacy than 2012. Mean antipsychotic numbers remained unchanged for >30-day hospitalizations. Patients admitted without antipsychotic polypharmacy with an affective spectrum disorder or aged 41-50 or over 51 years old were less likely to be discharged with antipsychotic polypharmacy when compared to patients with psychosis spectrum disorder or aged 18-30 years old.
Approximately three-quarters of admitted patients were treated with antipsychotic medication. Antipsychotic polypharmacy was observed across all psychiatric disorder categories, indicating potential off-label use. Addressing antipsychotic polypharmacy during treatment is challenging, even for specialised facilities. Rational antipsychotic prescribing, deprescribing protocols, and further prescription pattern research are needed. |
doi_str_mv | 10.1080/08039488.2023.2277820 |
format | article |
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Utilizing cohort data from an integrated dual diagnosis in-patient facility from patients hospitalized between 1 March 2012, to 31 December 2016, we compared the mean antipsychotic medication administered at admission and discharge and examined covariate associations with logistic regressions.
The study identified 907 hospital admissions, of which 641 were the first for each patient during the period. At admission, 74.1% received antipsychotics; polypharmacy spanned psychiatric disorders. categories. Patients with affective or personality spectrum disorders were less likely to have antipsychotic polypharmacy upon admission compared to those with psychosis spectrum disorders. 2013-2016 admissions presented less polypharmacy than 2012. Mean antipsychotic numbers remained unchanged for >30-day hospitalizations. Patients admitted without antipsychotic polypharmacy with an affective spectrum disorder or aged 41-50 or over 51 years old were less likely to be discharged with antipsychotic polypharmacy when compared to patients with psychosis spectrum disorder or aged 18-30 years old.
Approximately three-quarters of admitted patients were treated with antipsychotic medication. Antipsychotic polypharmacy was observed across all psychiatric disorder categories, indicating potential off-label use. Addressing antipsychotic polypharmacy during treatment is challenging, even for specialised facilities. Rational antipsychotic prescribing, deprescribing protocols, and further prescription pattern research are needed.</description><identifier>ISSN: 0803-9488</identifier><identifier>EISSN: 1502-4725</identifier><identifier>DOI: 10.1080/08039488.2023.2277820</identifier><identifier>PMID: 37938028</identifier><language>eng</language><publisher>England</publisher><ispartof>Nordic journal of psychiatry, 2024-02, Vol.78 (2), p.112-119</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c309t-73c1e894ba5ca5987a4131205884b295a1350128cb2e1c5306b05ea2b75f859f3</citedby><cites>FETCH-LOGICAL-c309t-73c1e894ba5ca5987a4131205884b295a1350128cb2e1c5306b05ea2b75f859f3</cites><orcidid>0000-0002-6589-3116</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37938028$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jobe, Lei Blandin</creatorcontrib><creatorcontrib>Mårtensson, Solvej</creatorcontrib><creatorcontrib>Düring, Signe Wegmann</creatorcontrib><title>Polypharmacy in antipsychotic pharmacological treatment among patients with dual diagnosis in Denmark</title><title>Nordic journal of psychiatry</title><addtitle>Nord J Psychiatry</addtitle><description>Antipsychotic polypharmacy is prevalent, however literature on antipsychotic polypharmacy during treatment among patients with dual diagnosis is largely non-existent. This study aims to investigating the extent of antipsychotic polypharmacy dual diagnosis patients during hospitalisations.
Utilizing cohort data from an integrated dual diagnosis in-patient facility from patients hospitalized between 1 March 2012, to 31 December 2016, we compared the mean antipsychotic medication administered at admission and discharge and examined covariate associations with logistic regressions.
The study identified 907 hospital admissions, of which 641 were the first for each patient during the period. At admission, 74.1% received antipsychotics; polypharmacy spanned psychiatric disorders. categories. Patients with affective or personality spectrum disorders were less likely to have antipsychotic polypharmacy upon admission compared to those with psychosis spectrum disorders. 2013-2016 admissions presented less polypharmacy than 2012. Mean antipsychotic numbers remained unchanged for >30-day hospitalizations. Patients admitted without antipsychotic polypharmacy with an affective spectrum disorder or aged 41-50 or over 51 years old were less likely to be discharged with antipsychotic polypharmacy when compared to patients with psychosis spectrum disorder or aged 18-30 years old.
Approximately three-quarters of admitted patients were treated with antipsychotic medication. Antipsychotic polypharmacy was observed across all psychiatric disorder categories, indicating potential off-label use. Addressing antipsychotic polypharmacy during treatment is challenging, even for specialised facilities. Rational antipsychotic prescribing, deprescribing protocols, and further prescription pattern research are needed.</description><issn>0803-9488</issn><issn>1502-4725</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo9kMlOwzAQQC0EoqXwCSAfuaSM7bi2j6isUiU4wDlyXKc1JHGIHaH8PYmachiNRvNm0UPomsCSgIS7IZhKpVxSoGxJqRCSwgmaEw40SQXlp2g-MskIzdBFCF8AwBhV52jGhGISqJwj--7LvtnrttKmx67Guo6uCb3Z--gMnjq-9DtndIlja3WsbB2xrny9w42ObqgC_nVxj7fdgGyd3tU-uDBue7B1pdvvS3RW6DLYqykv0OfT48f6Jdm8Pb-u7zeJYaBiIpghVqo019xorqTQKWGEApcyzanimjAOhEqTU0sMZ7DKgVtNc8ELyVXBFuj2sLdp_U9nQ8wqF4wtS11b34WMSilSsQImBpQfUNP6EFpbZE3rhl_7jEA2Gs6OhrPRcDYZHuZuphNdXtnt_9RRKfsD0f93Yw</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Jobe, Lei Blandin</creator><creator>Mårtensson, Solvej</creator><creator>Düring, Signe Wegmann</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6589-3116</orcidid></search><sort><creationdate>20240201</creationdate><title>Polypharmacy in antipsychotic pharmacological treatment among patients with dual diagnosis in Denmark</title><author>Jobe, Lei Blandin ; Mårtensson, Solvej ; Düring, Signe Wegmann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-73c1e894ba5ca5987a4131205884b295a1350128cb2e1c5306b05ea2b75f859f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jobe, Lei Blandin</creatorcontrib><creatorcontrib>Mårtensson, Solvej</creatorcontrib><creatorcontrib>Düring, Signe Wegmann</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nordic journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jobe, Lei Blandin</au><au>Mårtensson, Solvej</au><au>Düring, Signe Wegmann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polypharmacy in antipsychotic pharmacological treatment among patients with dual diagnosis in Denmark</atitle><jtitle>Nordic journal of psychiatry</jtitle><addtitle>Nord J Psychiatry</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>78</volume><issue>2</issue><spage>112</spage><epage>119</epage><pages>112-119</pages><issn>0803-9488</issn><eissn>1502-4725</eissn><abstract>Antipsychotic polypharmacy is prevalent, however literature on antipsychotic polypharmacy during treatment among patients with dual diagnosis is largely non-existent. This study aims to investigating the extent of antipsychotic polypharmacy dual diagnosis patients during hospitalisations.
Utilizing cohort data from an integrated dual diagnosis in-patient facility from patients hospitalized between 1 March 2012, to 31 December 2016, we compared the mean antipsychotic medication administered at admission and discharge and examined covariate associations with logistic regressions.
The study identified 907 hospital admissions, of which 641 were the first for each patient during the period. At admission, 74.1% received antipsychotics; polypharmacy spanned psychiatric disorders. categories. Patients with affective or personality spectrum disorders were less likely to have antipsychotic polypharmacy upon admission compared to those with psychosis spectrum disorders. 2013-2016 admissions presented less polypharmacy than 2012. Mean antipsychotic numbers remained unchanged for >30-day hospitalizations. Patients admitted without antipsychotic polypharmacy with an affective spectrum disorder or aged 41-50 or over 51 years old were less likely to be discharged with antipsychotic polypharmacy when compared to patients with psychosis spectrum disorder or aged 18-30 years old.
Approximately three-quarters of admitted patients were treated with antipsychotic medication. Antipsychotic polypharmacy was observed across all psychiatric disorder categories, indicating potential off-label use. Addressing antipsychotic polypharmacy during treatment is challenging, even for specialised facilities. Rational antipsychotic prescribing, deprescribing protocols, and further prescription pattern research are needed.</abstract><cop>England</cop><pmid>37938028</pmid><doi>10.1080/08039488.2023.2277820</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6589-3116</orcidid></addata></record> |
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title | Polypharmacy in antipsychotic pharmacological treatment among patients with dual diagnosis in Denmark |
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