The effect of danger-associated molecular patterns on survival in acute graft versus host disease

Danger-associated molecular patterns (DAMPs) are molecules that can initiate and maintain robust inflammatory responses and were investigated in the pathogenesis of graft versus host disease (GvHD). Uric acid (UA) and fibrinogen (Fib) are DAMPs released from damaged tissue during allogeneic hematopo...

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Bibliographic Details
Published in:Bone marrow transplantation (Basingstoke) 2024-02, Vol.59 (2), p.189-195
Main Authors: Çelik, Serhat, Kaynar, Leylagül, Güven, Zeynep Tuğba, Atasever Duran, Kübra, Kontaş, Olgun, Keklik, Muzaffer, Ünal, Ali
Format: Article
Language:English
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Allografts
Cell Biology
Fibrinogen
Graft versus host disease
Graft-versus-host reaction
Hematology
Hematopoietic stem cells
Inflammation
Internal Medicine
Medicine
Medicine & Public Health
Pathogenesis
Public Health
Stem cell transplantation
Stem Cells
Survival
Therapeutic targets
Uric acid
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Summary:Danger-associated molecular patterns (DAMPs) are molecules that can initiate and maintain robust inflammatory responses and were investigated in the pathogenesis of graft versus host disease (GvHD). Uric acid (UA) and fibrinogen (Fib) are DAMPs released from damaged tissue during allogeneic hematopoietic stem cell transplantation (allo-HCT) and GvHD. We aimed to evaluate the effects of UA and Fib levels on survival in GvHD. One hundred seventy-four patients with grade 2-4 acute GvHD were included. UA and Fib levels were evaluated on allo-HCT day 0 and GvHD on days 0, 7, 14, and 28. Fib GvHD day 0 was the independent predictor for overall survival (OS), non-relapse mortality (NRM), and progression-free survival in multivariable models (HR 0.98, p  
ISSN:0268-3369
1476-5365
DOI:10.1038/s41409-023-02145-7