Loading…
The effect of danger-associated molecular patterns on survival in acute graft versus host disease
Danger-associated molecular patterns (DAMPs) are molecules that can initiate and maintain robust inflammatory responses and were investigated in the pathogenesis of graft versus host disease (GvHD). Uric acid (UA) and fibrinogen (Fib) are DAMPs released from damaged tissue during allogeneic hematopo...
Saved in:
| Published in: | Bone marrow transplantation (Basingstoke) 2024-02, Vol.59 (2), p.189-195 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | cdi_FETCH-LOGICAL-c326t-e72e918d27617f8514c2b39cc606405d427d2365f8a5b62cdb5c40f0916c2c553 |
| container_end_page | 195 |
| container_issue | 2 |
| container_start_page | 189 |
| container_title | Bone marrow transplantation (Basingstoke) |
| container_volume | 59 |
| creator | Çelik, Serhat Kaynar, Leylagül Güven, Zeynep Tuğba Atasever Duran, Kübra Kontaş, Olgun Keklik, Muzaffer Ünal, Ali |
| description | Danger-associated molecular patterns (DAMPs) are molecules that can initiate and maintain robust inflammatory responses and were investigated in the pathogenesis of graft versus host disease (GvHD). Uric acid (UA) and fibrinogen (Fib) are DAMPs released from damaged tissue during allogeneic hematopoietic stem cell transplantation (allo-HCT) and GvHD. We aimed to evaluate the effects of UA and Fib levels on survival in GvHD. One hundred seventy-four patients with grade 2-4 acute GvHD were included. UA and Fib levels were evaluated on allo-HCT day 0 and GvHD on days 0, 7, 14, and 28. Fib GvHD day 0 was the independent predictor for overall survival (OS), non-relapse mortality (NRM), and progression-free survival in multivariable models (HR 0.98,
p
|
| doi_str_mv | 10.1038/s41409-023-02145-7 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2887477868</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2923163504</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-e72e918d27617f8514c2b39cc606405d427d2365f8a5b62cdb5c40f0916c2c553</originalsourceid><addsrcrecordid>eNp9kT1PHDEQhq2IKBwffyAFskSTZhN_21tGCBIkpDRQWz7vGBbtrQ-P9yT-fQxHEokixWiKeeadj5eQz5x95Uy6b6i4Yn3HhGzBle7sB7LiyppOS6MPyIoJ4zopTX9IjhAfGeNKMf2JHErbS20dX5Fw-wAUUoJYaU50CPM9lC4g5jiGCgPd5AniMoVCt6FWKDPSPFNcym7chYmOMw1xqUDvS0iV7qDggvQhY6XDiBAQTsjHFCaE07d8TO6uLm8vfnY3v35cX3y_6aIUpnZgBfTcDcIabpPTXEWxln2Mhpm29KCEHUQ7K7mg10bEYa2jYon13EQRtZbH5Mted1vy0wJY_WbECNMUZsgLeuGcVdY64xp6_g59zEuZ23Ze9EJyIzVTjRJ7KpaMWCD5bRk3oTx7zvyLAX5vgG8G-FcDvG1NZ2_Sy3oDw9-WPx9vgNwD2Eovz_43-z-yvwH9mpA7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2923163504</pqid></control><display><type>article</type><title>The effect of danger-associated molecular patterns on survival in acute graft versus host disease</title><source>Nexis UK</source><source>Springer Link</source><creator>Çelik, Serhat ; Kaynar, Leylagül ; Güven, Zeynep Tuğba ; Atasever Duran, Kübra ; Kontaş, Olgun ; Keklik, Muzaffer ; Ünal, Ali</creator><creatorcontrib>Çelik, Serhat ; Kaynar, Leylagül ; Güven, Zeynep Tuğba ; Atasever Duran, Kübra ; Kontaş, Olgun ; Keklik, Muzaffer ; Ünal, Ali</creatorcontrib><description>Danger-associated molecular patterns (DAMPs) are molecules that can initiate and maintain robust inflammatory responses and were investigated in the pathogenesis of graft versus host disease (GvHD). Uric acid (UA) and fibrinogen (Fib) are DAMPs released from damaged tissue during allogeneic hematopoietic stem cell transplantation (allo-HCT) and GvHD. We aimed to evaluate the effects of UA and Fib levels on survival in GvHD. One hundred seventy-four patients with grade 2-4 acute GvHD were included. UA and Fib levels were evaluated on allo-HCT day 0 and GvHD on days 0, 7, 14, and 28. Fib GvHD day 0 was the independent predictor for overall survival (OS), non-relapse mortality (NRM), and progression-free survival in multivariable models (HR 0.98,
p
< 0.001; HR 0.98,
p
= 0.001, HR 0.98,
p
= 0.006, respectively). Also UA GvHD day 28 was the independent predictor for OS and NRM (HR 0.77,
p
= 0.004; HR 0.76,
p
= 0.011, respectively). Our results indicated that hypouricemia and hypofibrinogenemia were associated with a significantly shorter OS and higher NRM. UA and Fib are remarkable molecules in GvHD because they are routinely utilized, readily available, can be therapeutic targets, and have DAMPs and antioxidant features.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/s41409-023-02145-7</identifier><identifier>PMID: 37935781</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/100 ; 38/56 ; 631/250/1854/2812 ; 631/250/262/2106/2517 ; 631/532/1542 ; 692/308/2171 ; 692/699/1541/1990/283/1897 ; Allografts ; Cell Biology ; Fibrinogen ; Graft versus host disease ; Graft-versus-host reaction ; Hematology ; Hematopoietic stem cells ; Inflammation ; Internal Medicine ; Medicine ; Medicine & Public Health ; Pathogenesis ; Public Health ; Stem cell transplantation ; Stem Cells ; Survival ; Therapeutic targets ; Uric acid</subject><ispartof>Bone marrow transplantation (Basingstoke), 2024-02, Vol.59 (2), p.189-195</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Nature Limited.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-e72e918d27617f8514c2b39cc606405d427d2365f8a5b62cdb5c40f0916c2c553</cites><orcidid>0000-0002-2035-9462 ; 0000-0002-1052-9800 ; 0000-0002-6426-5249</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37935781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Çelik, Serhat</creatorcontrib><creatorcontrib>Kaynar, Leylagül</creatorcontrib><creatorcontrib>Güven, Zeynep Tuğba</creatorcontrib><creatorcontrib>Atasever Duran, Kübra</creatorcontrib><creatorcontrib>Kontaş, Olgun</creatorcontrib><creatorcontrib>Keklik, Muzaffer</creatorcontrib><creatorcontrib>Ünal, Ali</creatorcontrib><title>The effect of danger-associated molecular patterns on survival in acute graft versus host disease</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><addtitle>Bone Marrow Transplant</addtitle><description>Danger-associated molecular patterns (DAMPs) are molecules that can initiate and maintain robust inflammatory responses and were investigated in the pathogenesis of graft versus host disease (GvHD). Uric acid (UA) and fibrinogen (Fib) are DAMPs released from damaged tissue during allogeneic hematopoietic stem cell transplantation (allo-HCT) and GvHD. We aimed to evaluate the effects of UA and Fib levels on survival in GvHD. One hundred seventy-four patients with grade 2-4 acute GvHD were included. UA and Fib levels were evaluated on allo-HCT day 0 and GvHD on days 0, 7, 14, and 28. Fib GvHD day 0 was the independent predictor for overall survival (OS), non-relapse mortality (NRM), and progression-free survival in multivariable models (HR 0.98,
p
< 0.001; HR 0.98,
p
= 0.001, HR 0.98,
p
= 0.006, respectively). Also UA GvHD day 28 was the independent predictor for OS and NRM (HR 0.77,
p
= 0.004; HR 0.76,
p
= 0.011, respectively). Our results indicated that hypouricemia and hypofibrinogenemia were associated with a significantly shorter OS and higher NRM. UA and Fib are remarkable molecules in GvHD because they are routinely utilized, readily available, can be therapeutic targets, and have DAMPs and antioxidant features.</description><subject>13/100</subject><subject>38/56</subject><subject>631/250/1854/2812</subject><subject>631/250/262/2106/2517</subject><subject>631/532/1542</subject><subject>692/308/2171</subject><subject>692/699/1541/1990/283/1897</subject><subject>Allografts</subject><subject>Cell Biology</subject><subject>Fibrinogen</subject><subject>Graft versus host disease</subject><subject>Graft-versus-host reaction</subject><subject>Hematology</subject><subject>Hematopoietic stem cells</subject><subject>Inflammation</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Pathogenesis</subject><subject>Public Health</subject><subject>Stem cell transplantation</subject><subject>Stem Cells</subject><subject>Survival</subject><subject>Therapeutic targets</subject><subject>Uric acid</subject><issn>0268-3369</issn><issn>1476-5365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kT1PHDEQhq2IKBwffyAFskSTZhN_21tGCBIkpDRQWz7vGBbtrQ-P9yT-fQxHEokixWiKeeadj5eQz5x95Uy6b6i4Yn3HhGzBle7sB7LiyppOS6MPyIoJ4zopTX9IjhAfGeNKMf2JHErbS20dX5Fw-wAUUoJYaU50CPM9lC4g5jiGCgPd5AniMoVCt6FWKDPSPFNcym7chYmOMw1xqUDvS0iV7qDggvQhY6XDiBAQTsjHFCaE07d8TO6uLm8vfnY3v35cX3y_6aIUpnZgBfTcDcIabpPTXEWxln2Mhpm29KCEHUQ7K7mg10bEYa2jYon13EQRtZbH5Mted1vy0wJY_WbECNMUZsgLeuGcVdY64xp6_g59zEuZ23Ze9EJyIzVTjRJ7KpaMWCD5bRk3oTx7zvyLAX5vgG8G-FcDvG1NZ2_Sy3oDw9-WPx9vgNwD2Eovz_43-z-yvwH9mpA7</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Çelik, Serhat</creator><creator>Kaynar, Leylagül</creator><creator>Güven, Zeynep Tuğba</creator><creator>Atasever Duran, Kübra</creator><creator>Kontaş, Olgun</creator><creator>Keklik, Muzaffer</creator><creator>Ünal, Ali</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2035-9462</orcidid><orcidid>https://orcid.org/0000-0002-1052-9800</orcidid><orcidid>https://orcid.org/0000-0002-6426-5249</orcidid></search><sort><creationdate>20240201</creationdate><title>The effect of danger-associated molecular patterns on survival in acute graft versus host disease</title><author>Çelik, Serhat ; Kaynar, Leylagül ; Güven, Zeynep Tuğba ; Atasever Duran, Kübra ; Kontaş, Olgun ; Keklik, Muzaffer ; Ünal, Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-e72e918d27617f8514c2b39cc606405d427d2365f8a5b62cdb5c40f0916c2c553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>13/100</topic><topic>38/56</topic><topic>631/250/1854/2812</topic><topic>631/250/262/2106/2517</topic><topic>631/532/1542</topic><topic>692/308/2171</topic><topic>692/699/1541/1990/283/1897</topic><topic>Allografts</topic><topic>Cell Biology</topic><topic>Fibrinogen</topic><topic>Graft versus host disease</topic><topic>Graft-versus-host reaction</topic><topic>Hematology</topic><topic>Hematopoietic stem cells</topic><topic>Inflammation</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Pathogenesis</topic><topic>Public Health</topic><topic>Stem cell transplantation</topic><topic>Stem Cells</topic><topic>Survival</topic><topic>Therapeutic targets</topic><topic>Uric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Çelik, Serhat</creatorcontrib><creatorcontrib>Kaynar, Leylagül</creatorcontrib><creatorcontrib>Güven, Zeynep Tuğba</creatorcontrib><creatorcontrib>Atasever Duran, Kübra</creatorcontrib><creatorcontrib>Kontaş, Olgun</creatorcontrib><creatorcontrib>Keklik, Muzaffer</creatorcontrib><creatorcontrib>Ünal, Ali</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bone marrow transplantation (Basingstoke)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Çelik, Serhat</au><au>Kaynar, Leylagül</au><au>Güven, Zeynep Tuğba</au><au>Atasever Duran, Kübra</au><au>Kontaş, Olgun</au><au>Keklik, Muzaffer</au><au>Ünal, Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of danger-associated molecular patterns on survival in acute graft versus host disease</atitle><jtitle>Bone marrow transplantation (Basingstoke)</jtitle><stitle>Bone Marrow Transplant</stitle><addtitle>Bone Marrow Transplant</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>59</volume><issue>2</issue><spage>189</spage><epage>195</epage><pages>189-195</pages><issn>0268-3369</issn><eissn>1476-5365</eissn><abstract>Danger-associated molecular patterns (DAMPs) are molecules that can initiate and maintain robust inflammatory responses and were investigated in the pathogenesis of graft versus host disease (GvHD). Uric acid (UA) and fibrinogen (Fib) are DAMPs released from damaged tissue during allogeneic hematopoietic stem cell transplantation (allo-HCT) and GvHD. We aimed to evaluate the effects of UA and Fib levels on survival in GvHD. One hundred seventy-four patients with grade 2-4 acute GvHD were included. UA and Fib levels were evaluated on allo-HCT day 0 and GvHD on days 0, 7, 14, and 28. Fib GvHD day 0 was the independent predictor for overall survival (OS), non-relapse mortality (NRM), and progression-free survival in multivariable models (HR 0.98,
p
< 0.001; HR 0.98,
p
= 0.001, HR 0.98,
p
= 0.006, respectively). Also UA GvHD day 28 was the independent predictor for OS and NRM (HR 0.77,
p
= 0.004; HR 0.76,
p
= 0.011, respectively). Our results indicated that hypouricemia and hypofibrinogenemia were associated with a significantly shorter OS and higher NRM. UA and Fib are remarkable molecules in GvHD because they are routinely utilized, readily available, can be therapeutic targets, and have DAMPs and antioxidant features.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>37935781</pmid><doi>10.1038/s41409-023-02145-7</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2035-9462</orcidid><orcidid>https://orcid.org/0000-0002-1052-9800</orcidid><orcidid>https://orcid.org/0000-0002-6426-5249</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-3369 |
| ispartof | Bone marrow transplantation (Basingstoke), 2024-02, Vol.59 (2), p.189-195 |
| issn | 0268-3369 1476-5365 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2887477868 |
| source | Nexis UK; Springer Link |
| subjects | 13/100 38/56 631/250/1854/2812 631/250/262/2106/2517 631/532/1542 692/308/2171 692/699/1541/1990/283/1897 Allografts Cell Biology Fibrinogen Graft versus host disease Graft-versus-host reaction Hematology Hematopoietic stem cells Inflammation Internal Medicine Medicine Medicine & Public Health Pathogenesis Public Health Stem cell transplantation Stem Cells Survival Therapeutic targets Uric acid |
| title | The effect of danger-associated molecular patterns on survival in acute graft versus host disease |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T21%3A57%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effect%20of%20danger-associated%20molecular%20patterns%20on%20survival%20in%20acute%20graft%20versus%20host%20disease&rft.jtitle=Bone%20marrow%20transplantation%20(Basingstoke)&rft.au=%C3%87elik,%20Serhat&rft.date=2024-02-01&rft.volume=59&rft.issue=2&rft.spage=189&rft.epage=195&rft.pages=189-195&rft.issn=0268-3369&rft.eissn=1476-5365&rft_id=info:doi/10.1038/s41409-023-02145-7&rft_dat=%3Cproquest_cross%3E2923163504%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c326t-e72e918d27617f8514c2b39cc606405d427d2365f8a5b62cdb5c40f0916c2c553%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2923163504&rft_id=info:pmid/37935781&rfr_iscdi=true |