Pretreatment synthetic MRI features for triple-negative breast cancer

• Published in: Clinical radiology 2024-02, Vol.79 (2), p.e219-e226
• Main Authors: Zhang, Q, Zhao, Y, Nie, J, Long, Q, Wang, X, Gong, G, Liao, L, Yi, X, Chen, B T
• Format: Article
• Language: English
• Subjects: Breast - diagnostic imaging; Breast - pathology; Breast Neoplasms - pathology; Female; Humans; Magnetic Resonance Imaging - methods; Prospective Studies; Retrospective Studies; Triple Negative Breast Neoplasms - diagnostic imaging; Triple Negative Breast Neoplasms - pathology
• ISSN: 0009-9260; 1365-229X; 1365-229X
• DOI: 10.1016/j.crad.2023.10.015

To evaluate the quantitative parameters derived from synthetic magnetic resonance imaging (SyMRI) for predicting triple-negative breast cancer (TNBC). This prospective study enrolled participants with invasive ductal breast carcinoma (IDBC) and separated them into a TNBC group and a Non-TNBC group. Preoperative breast MRI included both the SyMRI and conventional MRI sequences. The quantitative parameters derived from the SyMRI included T1 and T2 relaxation times, proton density (PD), and their standard deviations (SD). Clinicopathological characteristics, conventional MRI findings, and quantitative synthetic parameters were assessed for all participants. Multivariable logistic regression analysis was performed to determine the potential independent imaging predictors for TNBC preoperatively. Receiver operating characteristic (ROC) curve analysis was used to evaluate the performance of these parameters. A total of 231 participants with histopathological proven IDBC were included in this study (n=46 in the TNBC group and n=185 in the Non-TNBC group). The TNBC group had significantly larger tumour size (p=0.011) and more frequent intratumoural cystic or necrotic lesions (p