Balancing anticoagulation and hemostasis in an infant with severe hemophilia A during cardiac transplantation: Review of the literature and development of a surgical protocol

Hemophilia A is a disorder resulting in a deficiency of clotting factor VIII that can lead to life‐threatening bleeding. Evidence‐based guidelines for surgical interventions like cardiac surgery are limited. Anticoagulation is necessary for cardiac bypass, thus risk of bleeding in a patient with hem...

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Bibliographic Details
Published in:Pediatric blood & cancer 2024-01, Vol.71 (1), p.e30759-n/a
Main Authors: Regling, Katherine, Sehgal, Swati, Hollon, Wendy, Rayner, Patricia, Stricker, Lori, Sarnaik, Ajit, Sassalos, Peter, Al‐Ahmadi, Mamdouh, Rajpurkar, Madhvi, Chitlur, Meera B.
Format: Article
Language:English
Subjects:
Bleeding
Cardiomyopathy
Clotting
Coagulation factors
Dilated cardiomyopathy
Heart surgery
Heart transplantation
Hematology
Hemophilia
hemophilia A
Hemostasis
Infants
Literature reviews
Oncology
pediatric
Pediatrics
protocol
transplant
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Summary:Hemophilia A is a disorder resulting in a deficiency of clotting factor VIII that can lead to life‐threatening bleeding. Evidence‐based guidelines for surgical interventions like cardiac surgery are limited. Anticoagulation is necessary for cardiac bypass, thus risk of bleeding in a patient with hemophilia is increased and requires careful attention to maintain hemostasis. We report the first infant with severe hemophilia A and dilated cardiomyopathy who underwent successful cardiac transplantation, and review the literature on previous cardiac transplant cases in congenital hemophilia. To ensure safe and effective management, a multidisciplinary approach was used to develop the surgical protocol for transplant.
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.30759