Polymorphisms on rs9939609 FTO and rs17782313 MC4R genes in children and adolescent obesity: A systematic review

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2021-11, Vol.91-92, p.111474-111474, Article 111474
• Main Authors: Resende, Cristina Maria Mendes, Silva, Helker Albuquerque Macedo da, Campello, Camilla Porto, Ferraz, Lívia Almeida Amaral, de Lima, Elker Lene Santos, Beserra, Maria Aparecida, Muniz, Maria Tereza Cartaxo, da Silva, Lygia Maria Pereira
• Format: Article
• Language: English
• Subjects: Adolescent; Adolescents; Age; alleles; Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics; Bias; Body Mass Index; Body weight; Check lists; Children; Children & youth; Disease; Ethnicity; Gene Frequency; Genes; Genetic Predisposition to Disease; Genotype; Humans; meta-analysis; nationalities and ethnic groups; nutrition; Nutritional status; Obesity; Overweight; Pediatric Obesity - genetics; Pediatrics; phenotype; Phenotypes; Polymorphism; Polymorphism, Single Nucleotide; Population; protective effect; Receptor, Melanocortin, Type 4 - genetics; Research methodology; Reviews; Risk; rs17782313; rs9939609; synergism; Synergistic effect; Systematic review; Teenagers
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/j.nut.2021.111474

The aim of this review was to assess whether the presence of rs9939609 and rs17782313 polymorphisms increase the risk for obesity among children and adolescents. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist and it was registered in PROSPERO. The search was performed in the PubMed/Medline, The Cochrane Library, and Web of Science databases. The risk of bias of the studies was accessed using the Newcastle-Ottawa scale and JBI Critical Appraisal Checklist for Analytical. The search of the databases retrieved 859 references. Twelve studies were eligible to be included in this systematic review. Five studies founded a positive association between overweight and obesity in children and adolescents with the presence of the rs17783213 and four studies with rs9939609. Three studies did not find an association between overweight and obesity in children and adolescents with the presence of rs17782313 or rs9939609. One found a protective effect for obesity in individuals with risk A allele referring to rs9939609, one found a synergistic effect in relation to the presence of polymorphisms rs17782313 and rs9939609 for obese phenotype, and one observed that the presence together of the rs9939609, rs17782313, and rs12970134 MC4R were significant for the presence of obesity in children and adolescents. The results suggest that depending on the population evaluated and ethnicity, the polymorphisms rs17782313 and rs9939609 could be associated with overweight and obesity in children and adolescents.