Simple quantitative planimetric measurement of nigrosome-1 for clinical settings

Loss of MRI hyperintense signal in nigrosome-1 (assessed with susceptibility-weighted imaging) is a biomarker for Parkinson's disease (PD). Current clinical practice involves subjectively rating the appearance of nigrosome-1 which is challenging. The study aimed to test and compare a simple met...

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Bibliographic Details
Published in:Journal of the neurological sciences 2023-11, Vol.454, p.120857-120857, Article 120857
Main Authors: Chau, Minh T, Agzarian, Marc, Wilcox, Robert A, Dwyer, Andrew, Bezak, Eva, Todd, Gabrielle
Format: Article
Language:English
Subjects:
Essential Tremor - diagnostic imaging
Humans
Magnetic Resonance Imaging - methods
Parkinson Disease - diagnostic imaging
Reproducibility of Results
Substantia Nigra
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Summary:Loss of MRI hyperintense signal in nigrosome-1 (assessed with susceptibility-weighted imaging) is a biomarker for Parkinson's disease (PD). Current clinical practice involves subjectively rating the appearance of nigrosome-1 which is challenging. The study aimed to test and compare a simple method for quantifying nigrosome-1 with the current subjective rating method. Two experienced neuroradiologists measured area of hyperintense signal in nigrosome-1 (quantitative method) and rated nigrosome-1 appearance (as normal, attenuated, or absent; subjective method) in 42 patients encompassing the full spectrum of nigrosome-1 integrity (21 patients aged 55.5 ± 20.9 years with Essential tremor (ET) and a subset of 21 patients aged 69.6 ± 8.6 years with PD). Neuroradiologists were blinded to each other's measurements, clinical notes, and patient group. Both methods yielded a significant difference between the groups (PD vs ET; p 
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2023.120857