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Combined versus standalone XEN45 Gel Stent implantation in either phakic or pseudophakic patients: a case-matched study
Purpose To determine differing outcomes among either phakic or pseudophakic patients who received standalone XEN45 Gel Stent (Allergan, an AbbVie Company, CA, USA) implantation and patients who underwent combined surgery with phacoemulsification. Methods This retrospective single-center study involv...
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| Published in: | Graefe's archive for clinical and experimental ophthalmology 2024-04, Vol.262 (4), p.1253-1262 |
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| container_title | Graefe's archive for clinical and experimental ophthalmology |
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| creator | Kiessling, David Rennings, Corinna Hild, Matthias Lappas, Alexandra Dietlein, Thomas Stefan Roessler, Gernot Franz Widder, Randolf Alexander |
| description | Purpose
To determine differing outcomes among either phakic or pseudophakic patients who received standalone XEN45 Gel Stent (Allergan, an AbbVie Company, CA, USA) implantation and patients who underwent combined surgery with phacoemulsification.
Methods
This retrospective single-center study involved 180 eyes of 180 participants who underwent XEN45 Gel Stent implantation, of which 60 eyes received combined surgery with phacoemulsification (combined group). Standalone stent implantation was performed on 60 phakic (phakic group) and on 60 pseudophakic eyes (pseudophakic group). The groups were matched in a ratio of 1:1:1 based on multiple criteria. Successful surgery was defined by three scores: IOP at the longest follow-up of |
| doi_str_mv | 10.1007/s00417-023-06283-y |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2889239907</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3032844154</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-a270f1ed950e7a48a8b15a2caf2029ecfa1d932263282bf8408ffd0278d1c7b3</originalsourceid><addsrcrecordid>eNp9kUFv1DAQhS0EotvCH-CALHHhYhjbSe1wQ6vSIlVwoIe9WY49YVMSO9gOaP89hl1A4sDJY8333szoEfKMwysOoF5ngIYrBkIyuBRassMDsuGNbJkCsXtINqAEZ1qK3Rk5z_keKi9b_picSdW1oFq-Id-3ce7HgJ5-w5TXTHOxwdspBqS7qw9NS69xop8KhkLHeZlsKLaMMdAxUBzLHhNd9vbL6GisVcbVx9N_qVxV5TfUUmczstkWt6-Dcln94Ql5NNgp49PTe0Hu3l3dbW_Y7cfr99u3t8xJBYVZoWDg6Ou6qGyjre55a4WzgwDRoRss950U4lIKLfpBN6CHwYNQ2nOnenlBXh5tlxS_rpiLmcfscKp3YFyzEVp3QnYdqIq--Ae9j2sKdTkjodo3DW-bSokj5VLMOeFgljTONh0MB_MzFXNMxdRUzK9UzKGKnp-s135G_0fyO4YKyCOQayt8xvR39n9sfwAsHZkm</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3032844154</pqid></control><display><type>article</type><title>Combined versus standalone XEN45 Gel Stent implantation in either phakic or pseudophakic patients: a case-matched study</title><source>Springer Nature</source><creator>Kiessling, David ; Rennings, Corinna ; Hild, Matthias ; Lappas, Alexandra ; Dietlein, Thomas Stefan ; Roessler, Gernot Franz ; Widder, Randolf Alexander</creator><creatorcontrib>Kiessling, David ; Rennings, Corinna ; Hild, Matthias ; Lappas, Alexandra ; Dietlein, Thomas Stefan ; Roessler, Gernot Franz ; Widder, Randolf Alexander</creatorcontrib><description>Purpose
To determine differing outcomes among either phakic or pseudophakic patients who received standalone XEN45 Gel Stent (Allergan, an AbbVie Company, CA, USA) implantation and patients who underwent combined surgery with phacoemulsification.
Methods
This retrospective single-center study involved 180 eyes of 180 participants who underwent XEN45 Gel Stent implantation, of which 60 eyes received combined surgery with phacoemulsification (combined group). Standalone stent implantation was performed on 60 phakic (phakic group) and on 60 pseudophakic eyes (pseudophakic group). The groups were matched in a ratio of 1:1:1 based on multiple criteria. Successful surgery was defined by three scores: IOP at the longest follow-up of < 21 mmHg (Score A) or < 18 mmHg (Score B) and an IOP reduction > 20% or IOP ≤ 15 mmHg and an IOP reduction ≥ 40% (Score C). In all scores, one open conjunctival revision was allowed, and additional repeat surgery was considered a failure.
Results
After an average follow-up time interval of 20.6 ± 12.6 months, there was a mean IOP-reduction by 37% among the entire cohort. Comparative analysis between the three groups did not show significant differences regarding postoperative IOP, postoperative medication score, side effects, revision rate, repeat surgery rate or success rate. A dysfunctional stent was detected in eight eyes (4%) during open conjunctival revision in 76 eyes.
Conclusion
The clinical endpoints investigated did not differ significantly among either phakic or pseudophakic patients who received standalone stent implantation and patients who underwent combined surgery. However mean latency between primary stent implantation and first revision surgery after combined surgery was markedly shorter.</description><identifier>ISSN: 0721-832X</identifier><identifier>ISSN: 1435-702X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-023-06283-y</identifier><identifier>PMID: 37950751</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Comparative analysis ; Glaucoma ; Glaucoma Drainage Implants ; Glaucoma, Open-Angle ; Humans ; Implants ; Intraocular Pressure ; Latency ; Medicine ; Medicine & Public Health ; Ophthalmology ; Patients ; Retrospective Studies ; Stents ; Surgery ; Surgical outcomes ; Treatment Outcome</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2024-04, Vol.262 (4), p.1253-1262</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c370t-a270f1ed950e7a48a8b15a2caf2029ecfa1d932263282bf8408ffd0278d1c7b3</cites><orcidid>0000-0001-7487-1501</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37950751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kiessling, David</creatorcontrib><creatorcontrib>Rennings, Corinna</creatorcontrib><creatorcontrib>Hild, Matthias</creatorcontrib><creatorcontrib>Lappas, Alexandra</creatorcontrib><creatorcontrib>Dietlein, Thomas Stefan</creatorcontrib><creatorcontrib>Roessler, Gernot Franz</creatorcontrib><creatorcontrib>Widder, Randolf Alexander</creatorcontrib><title>Combined versus standalone XEN45 Gel Stent implantation in either phakic or pseudophakic patients: a case-matched study</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To determine differing outcomes among either phakic or pseudophakic patients who received standalone XEN45 Gel Stent (Allergan, an AbbVie Company, CA, USA) implantation and patients who underwent combined surgery with phacoemulsification.
Methods
This retrospective single-center study involved 180 eyes of 180 participants who underwent XEN45 Gel Stent implantation, of which 60 eyes received combined surgery with phacoemulsification (combined group). Standalone stent implantation was performed on 60 phakic (phakic group) and on 60 pseudophakic eyes (pseudophakic group). The groups were matched in a ratio of 1:1:1 based on multiple criteria. Successful surgery was defined by three scores: IOP at the longest follow-up of < 21 mmHg (Score A) or < 18 mmHg (Score B) and an IOP reduction > 20% or IOP ≤ 15 mmHg and an IOP reduction ≥ 40% (Score C). In all scores, one open conjunctival revision was allowed, and additional repeat surgery was considered a failure.
Results
After an average follow-up time interval of 20.6 ± 12.6 months, there was a mean IOP-reduction by 37% among the entire cohort. Comparative analysis between the three groups did not show significant differences regarding postoperative IOP, postoperative medication score, side effects, revision rate, repeat surgery rate or success rate. A dysfunctional stent was detected in eight eyes (4%) during open conjunctival revision in 76 eyes.
Conclusion
The clinical endpoints investigated did not differ significantly among either phakic or pseudophakic patients who received standalone stent implantation and patients who underwent combined surgery. However mean latency between primary stent implantation and first revision surgery after combined surgery was markedly shorter.</description><subject>Comparative analysis</subject><subject>Glaucoma</subject><subject>Glaucoma Drainage Implants</subject><subject>Glaucoma, Open-Angle</subject><subject>Humans</subject><subject>Implants</subject><subject>Intraocular Pressure</subject><subject>Latency</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Stents</subject><subject>Surgery</subject><subject>Surgical outcomes</subject><subject>Treatment Outcome</subject><issn>0721-832X</issn><issn>1435-702X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kUFv1DAQhS0EotvCH-CALHHhYhjbSe1wQ6vSIlVwoIe9WY49YVMSO9gOaP89hl1A4sDJY8333szoEfKMwysOoF5ngIYrBkIyuBRassMDsuGNbJkCsXtINqAEZ1qK3Rk5z_keKi9b_picSdW1oFq-Id-3ce7HgJ5-w5TXTHOxwdspBqS7qw9NS69xop8KhkLHeZlsKLaMMdAxUBzLHhNd9vbL6GisVcbVx9N_qVxV5TfUUmczstkWt6-Dcln94Ql5NNgp49PTe0Hu3l3dbW_Y7cfr99u3t8xJBYVZoWDg6Ou6qGyjre55a4WzgwDRoRss950U4lIKLfpBN6CHwYNQ2nOnenlBXh5tlxS_rpiLmcfscKp3YFyzEVp3QnYdqIq--Ae9j2sKdTkjodo3DW-bSokj5VLMOeFgljTONh0MB_MzFXNMxdRUzK9UzKGKnp-s135G_0fyO4YKyCOQayt8xvR39n9sfwAsHZkm</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Kiessling, David</creator><creator>Rennings, Corinna</creator><creator>Hild, Matthias</creator><creator>Lappas, Alexandra</creator><creator>Dietlein, Thomas Stefan</creator><creator>Roessler, Gernot Franz</creator><creator>Widder, Randolf Alexander</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7487-1501</orcidid></search><sort><creationdate>20240401</creationdate><title>Combined versus standalone XEN45 Gel Stent implantation in either phakic or pseudophakic patients: a case-matched study</title><author>Kiessling, David ; Rennings, Corinna ; Hild, Matthias ; Lappas, Alexandra ; Dietlein, Thomas Stefan ; Roessler, Gernot Franz ; Widder, Randolf Alexander</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-a270f1ed950e7a48a8b15a2caf2029ecfa1d932263282bf8408ffd0278d1c7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Comparative analysis</topic><topic>Glaucoma</topic><topic>Glaucoma Drainage Implants</topic><topic>Glaucoma, Open-Angle</topic><topic>Humans</topic><topic>Implants</topic><topic>Intraocular Pressure</topic><topic>Latency</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Patients</topic><topic>Retrospective Studies</topic><topic>Stents</topic><topic>Surgery</topic><topic>Surgical outcomes</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kiessling, David</creatorcontrib><creatorcontrib>Rennings, Corinna</creatorcontrib><creatorcontrib>Hild, Matthias</creatorcontrib><creatorcontrib>Lappas, Alexandra</creatorcontrib><creatorcontrib>Dietlein, Thomas Stefan</creatorcontrib><creatorcontrib>Roessler, Gernot Franz</creatorcontrib><creatorcontrib>Widder, Randolf Alexander</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kiessling, David</au><au>Rennings, Corinna</au><au>Hild, Matthias</au><au>Lappas, Alexandra</au><au>Dietlein, Thomas Stefan</au><au>Roessler, Gernot Franz</au><au>Widder, Randolf Alexander</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined versus standalone XEN45 Gel Stent implantation in either phakic or pseudophakic patients: a case-matched study</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>262</volume><issue>4</issue><spage>1253</spage><epage>1262</epage><pages>1253-1262</pages><issn>0721-832X</issn><issn>1435-702X</issn><eissn>1435-702X</eissn><abstract>Purpose
To determine differing outcomes among either phakic or pseudophakic patients who received standalone XEN45 Gel Stent (Allergan, an AbbVie Company, CA, USA) implantation and patients who underwent combined surgery with phacoemulsification.
Methods
This retrospective single-center study involved 180 eyes of 180 participants who underwent XEN45 Gel Stent implantation, of which 60 eyes received combined surgery with phacoemulsification (combined group). Standalone stent implantation was performed on 60 phakic (phakic group) and on 60 pseudophakic eyes (pseudophakic group). The groups were matched in a ratio of 1:1:1 based on multiple criteria. Successful surgery was defined by three scores: IOP at the longest follow-up of < 21 mmHg (Score A) or < 18 mmHg (Score B) and an IOP reduction > 20% or IOP ≤ 15 mmHg and an IOP reduction ≥ 40% (Score C). In all scores, one open conjunctival revision was allowed, and additional repeat surgery was considered a failure.
Results
After an average follow-up time interval of 20.6 ± 12.6 months, there was a mean IOP-reduction by 37% among the entire cohort. Comparative analysis between the three groups did not show significant differences regarding postoperative IOP, postoperative medication score, side effects, revision rate, repeat surgery rate or success rate. A dysfunctional stent was detected in eight eyes (4%) during open conjunctival revision in 76 eyes.
Conclusion
The clinical endpoints investigated did not differ significantly among either phakic or pseudophakic patients who received standalone stent implantation and patients who underwent combined surgery. However mean latency between primary stent implantation and first revision surgery after combined surgery was markedly shorter.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37950751</pmid><doi>10.1007/s00417-023-06283-y</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-7487-1501</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2024-04, Vol.262 (4), p.1253-1262 |
| issn | 0721-832X 1435-702X 1435-702X |
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| source | Springer Nature |
| subjects | Comparative analysis Glaucoma Glaucoma Drainage Implants Glaucoma, Open-Angle Humans Implants Intraocular Pressure Latency Medicine Medicine & Public Health Ophthalmology Patients Retrospective Studies Stents Surgery Surgical outcomes Treatment Outcome |
| title | Combined versus standalone XEN45 Gel Stent implantation in either phakic or pseudophakic patients: a case-matched study |
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