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Platelet-rich plasma for treating dry eye disease - A systematic review and meta-analysis
Dry eye disease has public health and economic significance. Platelet-rich plasma is rich in anti-inflammatory agents and growth factors, both beneficial for ocular surface repair. This study aimed to conduct a systematic review and meta-analysis to summarize the benefits of platelet-rich plasma for...
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| Published in: | Contact lens & anterior eye 2024-02, Vol.47 (1), p.102091-102091, Article 102091 |
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| creator | Kwaku Akowuah, Prince Junior Obinwanne, Chukwuemeka Owusu, Ebenezer Kyeremeh, Sylvester Bonsu, Kwaku Karikari, Lucy Akua Afriyie Akyaa Akomeah, Felicia Kyei Nkansah, Ernest Kobia-Acquah, Emmanuel |
| description | Dry eye disease has public health and economic significance. Platelet-rich plasma is rich in anti-inflammatory agents and growth factors, both beneficial for ocular surface repair. This study aimed to conduct a systematic review and meta-analysis to summarize the benefits of platelet-rich plasma for treating dry eye disease and its adverse effects.
Prospective comparative studies using platelet-rich plasma as monotherapy for dry eye disease were included for efficacy assessment. Before-after studies were included for adverse events assessment. Data sources included PubMed, Google Scholar, Web of Science, and Scopus. A systematic review and meta-analysis protocol was pre-registered on PROSPERO (CRD42022347982). PRISMA guidelines were followed. The National Health Institute (NIH) quality assessment tool for before-after studies, the Cochrane risk of bias tool (RoB2), and the methodological index for non-randomized studies were used to assess the risk of bias. Heterogeneity was assessed using the I
statistic.
19 studies (10 comparative and 9 before-after) were included in the systematic review and meta-analysis. The occurrence rate of adverse effects was 2.6 % (95 % CI: 0.5 - 4.7). The pooled standardized mean difference (SMD) for dry eye symptoms was 0.81 (95 % CI: 0.25 - 1.37; I
= 82 %; p |
| doi_str_mv | 10.1016/j.clae.2023.102091 |
| format | article |
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Prospective comparative studies using platelet-rich plasma as monotherapy for dry eye disease were included for efficacy assessment. Before-after studies were included for adverse events assessment. Data sources included PubMed, Google Scholar, Web of Science, and Scopus. A systematic review and meta-analysis protocol was pre-registered on PROSPERO (CRD42022347982). PRISMA guidelines were followed. The National Health Institute (NIH) quality assessment tool for before-after studies, the Cochrane risk of bias tool (RoB2), and the methodological index for non-randomized studies were used to assess the risk of bias. Heterogeneity was assessed using the I
statistic.
19 studies (10 comparative and 9 before-after) were included in the systematic review and meta-analysis. The occurrence rate of adverse effects was 2.6 % (95 % CI: 0.5 - 4.7). The pooled standardized mean difference (SMD) for dry eye symptoms was 0.81 (95 % CI: 0.25 - 1.37; I
= 82 %; p < 0.00001; Z = 2.84, p = 0.004); tear quality was 0.44 (95 % CI: 0.06 - 0.81; I
= 67 %; p = 0.003; Z = 2.26, p = 0.02); tear quantity was 0.45 (95 % CI: 0.03 - 0.88; I
= 74 %; p = 0.0003; Z = 2.10, p = 0.04); and corneal staining 0.72 (95 % CI: 0.14 - 1.30; I
= 85 %; p < 0.00001; Z = 2.43, p = 0.02).
The current study shows that platelet-rich plasma is efficacious in managing dry eye disease, significantly reducing dry eye signs and symptoms. Such significant improvements could translate to improved quality of life.</description><identifier>ISSN: 1367-0484</identifier><identifier>EISSN: 1476-5411</identifier><identifier>DOI: 10.1016/j.clae.2023.102091</identifier><identifier>PMID: 37951738</identifier><language>eng</language><publisher>England</publisher><subject>Dry Eye Syndromes - metabolism ; Dry Eye Syndromes - therapy ; Humans ; Platelet-Rich Plasma - metabolism ; Prospective Studies ; Quality of Life</subject><ispartof>Contact lens & anterior eye, 2024-02, Vol.47 (1), p.102091-102091, Article 102091</ispartof><rights>Copyright © 2023 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c303t-e7b793bd1a37f2f6a419a81702d0b5b46128bcc5d2ee96a96a05f982d48cdaee3</citedby><cites>FETCH-LOGICAL-c303t-e7b793bd1a37f2f6a419a81702d0b5b46128bcc5d2ee96a96a05f982d48cdaee3</cites><orcidid>0000-0003-1612-4350</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37951738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwaku Akowuah, Prince</creatorcontrib><creatorcontrib>Junior Obinwanne, Chukwuemeka</creatorcontrib><creatorcontrib>Owusu, Ebenezer</creatorcontrib><creatorcontrib>Kyeremeh, Sylvester</creatorcontrib><creatorcontrib>Bonsu, Kwaku</creatorcontrib><creatorcontrib>Karikari, Lucy Akua Afriyie</creatorcontrib><creatorcontrib>Akyaa Akomeah, Felicia</creatorcontrib><creatorcontrib>Kyei Nkansah, Ernest</creatorcontrib><creatorcontrib>Kobia-Acquah, Emmanuel</creatorcontrib><title>Platelet-rich plasma for treating dry eye disease - A systematic review and meta-analysis</title><title>Contact lens & anterior eye</title><addtitle>Cont Lens Anterior Eye</addtitle><description>Dry eye disease has public health and economic significance. Platelet-rich plasma is rich in anti-inflammatory agents and growth factors, both beneficial for ocular surface repair. This study aimed to conduct a systematic review and meta-analysis to summarize the benefits of platelet-rich plasma for treating dry eye disease and its adverse effects.
Prospective comparative studies using platelet-rich plasma as monotherapy for dry eye disease were included for efficacy assessment. Before-after studies were included for adverse events assessment. Data sources included PubMed, Google Scholar, Web of Science, and Scopus. A systematic review and meta-analysis protocol was pre-registered on PROSPERO (CRD42022347982). PRISMA guidelines were followed. The National Health Institute (NIH) quality assessment tool for before-after studies, the Cochrane risk of bias tool (RoB2), and the methodological index for non-randomized studies were used to assess the risk of bias. Heterogeneity was assessed using the I
statistic.
19 studies (10 comparative and 9 before-after) were included in the systematic review and meta-analysis. The occurrence rate of adverse effects was 2.6 % (95 % CI: 0.5 - 4.7). The pooled standardized mean difference (SMD) for dry eye symptoms was 0.81 (95 % CI: 0.25 - 1.37; I
= 82 %; p < 0.00001; Z = 2.84, p = 0.004); tear quality was 0.44 (95 % CI: 0.06 - 0.81; I
= 67 %; p = 0.003; Z = 2.26, p = 0.02); tear quantity was 0.45 (95 % CI: 0.03 - 0.88; I
= 74 %; p = 0.0003; Z = 2.10, p = 0.04); and corneal staining 0.72 (95 % CI: 0.14 - 1.30; I
= 85 %; p < 0.00001; Z = 2.43, p = 0.02).
The current study shows that platelet-rich plasma is efficacious in managing dry eye disease, significantly reducing dry eye signs and symptoms. Such significant improvements could translate to improved quality of life.</description><subject>Dry Eye Syndromes - metabolism</subject><subject>Dry Eye Syndromes - therapy</subject><subject>Humans</subject><subject>Platelet-Rich Plasma - metabolism</subject><subject>Prospective Studies</subject><subject>Quality of Life</subject><issn>1367-0484</issn><issn>1476-5411</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo9kEtPwzAQhC0EoqXwBzggH7mk-JXEPlYVLwkJDnDgZG3sDaRKmmK7oPx7UrUgrbSr2Zk5fIRccjbnjBc3q7lrAeeCCTkKghl-RKZclUWWK86Px1sWZcaUVhNyFuOKjSFj2CmZyNLkvJR6St5fWkjYYspC4z7ppoXYAa37QFNASM36g_owUByQ-iYiRKQZXdA4xITd-Hc04HeDPxTWnnaYIIM1tENs4jk5qaGNeHHYM_J2d_u6fMienu8fl4unzEkmU4ZlVRpZeQ6yrEVdgOIGNC-Z8KzKK1VwoSvnci8QTQHjsLw2WnilnQdEOSPX-95N6L-2GJPtmuiwbWGN_TZaobURiknGR6vYW13oYwxY201oOgiD5czukNqV3SG1O6R2j3QMXR36t1WH_j_yx1D-AqN1c38</recordid><startdate>202402</startdate><enddate>202402</enddate><creator>Kwaku Akowuah, Prince</creator><creator>Junior Obinwanne, Chukwuemeka</creator><creator>Owusu, Ebenezer</creator><creator>Kyeremeh, Sylvester</creator><creator>Bonsu, Kwaku</creator><creator>Karikari, Lucy Akua Afriyie</creator><creator>Akyaa Akomeah, Felicia</creator><creator>Kyei Nkansah, Ernest</creator><creator>Kobia-Acquah, Emmanuel</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1612-4350</orcidid></search><sort><creationdate>202402</creationdate><title>Platelet-rich plasma for treating dry eye disease - A systematic review and meta-analysis</title><author>Kwaku Akowuah, Prince ; Junior Obinwanne, Chukwuemeka ; Owusu, Ebenezer ; Kyeremeh, Sylvester ; Bonsu, Kwaku ; Karikari, Lucy Akua Afriyie ; Akyaa Akomeah, Felicia ; Kyei Nkansah, Ernest ; Kobia-Acquah, Emmanuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-e7b793bd1a37f2f6a419a81702d0b5b46128bcc5d2ee96a96a05f982d48cdaee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Dry Eye Syndromes - metabolism</topic><topic>Dry Eye Syndromes - therapy</topic><topic>Humans</topic><topic>Platelet-Rich Plasma - metabolism</topic><topic>Prospective Studies</topic><topic>Quality of Life</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwaku Akowuah, Prince</creatorcontrib><creatorcontrib>Junior Obinwanne, Chukwuemeka</creatorcontrib><creatorcontrib>Owusu, Ebenezer</creatorcontrib><creatorcontrib>Kyeremeh, Sylvester</creatorcontrib><creatorcontrib>Bonsu, Kwaku</creatorcontrib><creatorcontrib>Karikari, Lucy Akua Afriyie</creatorcontrib><creatorcontrib>Akyaa Akomeah, Felicia</creatorcontrib><creatorcontrib>Kyei Nkansah, Ernest</creatorcontrib><creatorcontrib>Kobia-Acquah, Emmanuel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Contact lens & anterior eye</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwaku Akowuah, Prince</au><au>Junior Obinwanne, Chukwuemeka</au><au>Owusu, Ebenezer</au><au>Kyeremeh, Sylvester</au><au>Bonsu, Kwaku</au><au>Karikari, Lucy Akua Afriyie</au><au>Akyaa Akomeah, Felicia</au><au>Kyei Nkansah, Ernest</au><au>Kobia-Acquah, Emmanuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet-rich plasma for treating dry eye disease - A systematic review and meta-analysis</atitle><jtitle>Contact lens & anterior eye</jtitle><addtitle>Cont Lens Anterior Eye</addtitle><date>2024-02</date><risdate>2024</risdate><volume>47</volume><issue>1</issue><spage>102091</spage><epage>102091</epage><pages>102091-102091</pages><artnum>102091</artnum><issn>1367-0484</issn><eissn>1476-5411</eissn><abstract>Dry eye disease has public health and economic significance. Platelet-rich plasma is rich in anti-inflammatory agents and growth factors, both beneficial for ocular surface repair. This study aimed to conduct a systematic review and meta-analysis to summarize the benefits of platelet-rich plasma for treating dry eye disease and its adverse effects.
Prospective comparative studies using platelet-rich plasma as monotherapy for dry eye disease were included for efficacy assessment. Before-after studies were included for adverse events assessment. Data sources included PubMed, Google Scholar, Web of Science, and Scopus. A systematic review and meta-analysis protocol was pre-registered on PROSPERO (CRD42022347982). PRISMA guidelines were followed. The National Health Institute (NIH) quality assessment tool for before-after studies, the Cochrane risk of bias tool (RoB2), and the methodological index for non-randomized studies were used to assess the risk of bias. Heterogeneity was assessed using the I
statistic.
19 studies (10 comparative and 9 before-after) were included in the systematic review and meta-analysis. The occurrence rate of adverse effects was 2.6 % (95 % CI: 0.5 - 4.7). The pooled standardized mean difference (SMD) for dry eye symptoms was 0.81 (95 % CI: 0.25 - 1.37; I
= 82 %; p < 0.00001; Z = 2.84, p = 0.004); tear quality was 0.44 (95 % CI: 0.06 - 0.81; I
= 67 %; p = 0.003; Z = 2.26, p = 0.02); tear quantity was 0.45 (95 % CI: 0.03 - 0.88; I
= 74 %; p = 0.0003; Z = 2.10, p = 0.04); and corneal staining 0.72 (95 % CI: 0.14 - 1.30; I
= 85 %; p < 0.00001; Z = 2.43, p = 0.02).
The current study shows that platelet-rich plasma is efficacious in managing dry eye disease, significantly reducing dry eye signs and symptoms. Such significant improvements could translate to improved quality of life.</abstract><cop>England</cop><pmid>37951738</pmid><doi>10.1016/j.clae.2023.102091</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-1612-4350</orcidid></addata></record> |
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| ispartof | Contact lens & anterior eye, 2024-02, Vol.47 (1), p.102091-102091, Article 102091 |
| issn | 1367-0484 1476-5411 |
| language | eng |
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| source | Elsevier |
| subjects | Dry Eye Syndromes - metabolism Dry Eye Syndromes - therapy Humans Platelet-Rich Plasma - metabolism Prospective Studies Quality of Life |
| title | Platelet-rich plasma for treating dry eye disease - A systematic review and meta-analysis |
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