Ferulic acid alleviates carp brain damage and growth inhibition caused by avermectin by modulating the Nrf2/Keap1 and NF-κB signaling pathways

• Published in: Pesticide biochemistry and physiology 2023-11, Vol.196, p.105590-105590, Article 105590
• Main Authors: Wang, Guanglu, Guo, Jiajia, Ma, Yeyun, Xin, Yue, Ji, Xiaomeng, Sun, Ying, Zhang, Jian, Dong, Jingquan
• Format: Article
• Language: English
• Subjects: Avermectin; Brain; Carp; Ferulic acid
• ISSN: 0048-3575; 1095-9939
• DOI: 10.1016/j.pestbp.2023.105590

The increasing concern over environmental pollution caused by the pesticide avermectin used in aquaculture has attracted significant attention. The use of avermectin, a neurotoxic pesticide, in aquatic environments leads to toxic effects on non-target organisms, particularly causing harm to fish. The phenolic compound ferulic acid possesses excellent anti-inflammatory and antioxidant capabilities. This study was conducted by establishing a chronic exposure experiment to avermectin, proposes the use of ferulic acid as a dietary additive to protect the carp brain from damage caused by exposure to avermectin. Furthermore, it investigates the anti-inflammatory and antioxidant effects of ferulic acid in the carp brain under chronic exposure to avermectin. The experimental results demonstrate that ferulic acid can alleviate brain tissue inflammation and oxidative stress by modulating the Nrf2/Keap1 and NF-κB signaling pathways. It protects the carp brain from chronic avermectin-induced damage, preserves the integrity of the carp blood-brain barrier, enhances the levels of feeding factors, and thereby alleviates carp growth inhibition. These findings provide new therapeutic strategies and a theoretical foundation for the sustainable development of carp aquaculture. [Display omitted] •Ferulic acid can alleviate carp brain damage induced by avermectin.•Ferulic acid alleviates carp brain inflammation by modulating the NF-κB pathway.•Ferulic acid modulates the Nrf2/Keap-1 signaling pathway to alleviate oxidative stress in carp brains.•Ferulic acid alleviates apoptosis in carp brain tissue induced by avermectin.•Ferulic acid alleviates carp growth inhibition caused by avermectin.