Development and application of a pseudotargeted lipidomics method for alkylglycerol analysis

Alkylglycerols (1-O-alkyl-sn-glycerols) are microscale but critical lipids in foods. Conventional lipidomics analysis often loses sight of alkylglycerol analysis. In this study, we developed a high coverage pseudotargeted lipidomics method for analyzing alkylglycerols. The developed method integrate...

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Published in:Food chemistry 2024-03, Vol.437, p.137926-137926, Article 137926
Main Authors: Wang, Hailong, Zhao, Yiqing, Wu, Tong, Hou, Yanmei, Chen, Xiaoyin, Shi, Jiachen, Liu, Kun, Liu, Yuanfa, Xu, Yong-Jiang
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container_start_page 137926
container_title Food chemistry
container_volume 437
creator Wang, Hailong
Zhao, Yiqing
Wu, Tong
Hou, Yanmei
Chen, Xiaoyin
Shi, Jiachen
Liu, Kun
Liu, Yuanfa
Xu, Yong-Jiang
description Alkylglycerols (1-O-alkyl-sn-glycerols) are microscale but critical lipids in foods. Conventional lipidomics analysis often loses sight of alkylglycerol analysis. In this study, we developed a high coverage pseudotargeted lipidomics method for analyzing alkylglycerols. The developed method integrated the advantages of GC-MS and LC-MS to profile alkylglycerol-type ether lipids comprehensively, with the help of a data processing Dart package termed FFIMA (Feature Fragments Information Matching Algorithm). The developed method exhibited competitive superiority to conventional lipidomics, such as wider coverage and higher accuracy. The validated method was assessed by three aquatic products and three milks. A total of 25 alkylglycerols, 107 diacylglycerol ethers, 21 monoacylglycerol ethers, 28 alkylglycerol-type ether phospholipids, and 35 plasmalogens were identified in the six foods. The results demonstrated that this method offers a comprehensive analysis of a wide spectrum of alkylglycerols.
doi_str_mv 10.1016/j.foodchem.2023.137926
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title Development and application of a pseudotargeted lipidomics method for alkylglycerol analysis
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