Fat-free mass index is a feasible predictor of insulin resistance in women with polycystic ovary syndrome: Evidence from a cross-sectional study

• Published in: Endocrine 2024-05, Vol.84 (2), p.420-426
• Main Authors: Guo, Jinru, Lin, Baiwei, Niu, Rui, Lu, Wenjing, He, Chunmei, Zhang, Mulin, Huang, Yinxiang, Chen, Xueqin, Liu, Changqin
• Format: Article
• Language: English
• Subjects: Adipose tissue; Adolescent; Adult; Body composition; Body Composition - physiology; Body fat; Body Mass Index; Cholesterol; Cross-Sectional Studies; Diabetes; Endocrinology; Fat-free body mass; Female; Humanities and Social Sciences; Humans; Insulin resistance; Insulin Resistance - physiology; Internal Medicine; Low density lipoprotein; Medicine; Medicine & Public Health; Metabolism; multidisciplinary; Original Article; Ovaries; Polycystic ovary syndrome; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - metabolism; Science; Young Adult
• ISSN: 1559-0100; 1355-008X; 1559-0100
• DOI: 10.1007/s12020-023-03591-5

Background Insulin resistance (IR) and adipose tissue amplify the metabolic and reproductive outcomes in women with polycystic ovary syndrome (PCOS). It has been widely discussed that body composition influences metabolic health. Still, limited studies were focused on the role of the fat-free mass index (FFMI) in assessing IR in PCOS women. Aims We aimed to explore the associations between FFMI/fat mass index (FMI) and IR in women with PCOS and assess the role of FFMI in predicting IR in women with PCOS. Methods In the current cross-sectional study, women with PCOS aged between 18 and 40 years were enrolled from October 2018 to July 2022. Baseline demographic information was obtained using standardized self-administered questionnaires. Anthropometric, biochemical, and hormonal information was measured and recorded by investigators. Pearson’s correlation and multivariable logistical regression were used to analyze the associations of FFMI/FMI and IR. In addition, receiver operating characteristic (ROC) curves were implied to measure the predictive role of FFMI/FMI for IR in women with PCOS. Results A total of 371 women with PCOS, reproductive age (27.58 ± 4.89) were enrolled. PCOS women with IR have higher levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), homeostatic model assessment of insulin resistance (HOMA-IR), FMI, and FFMI than that without IR. FMI ( r  = 0.492, p