Revolutionizing the battle against locally advanced breast cancer: A comprehensive insight into neoadjuvant radiotherapy

Breast cancer (BC) constitutes one of the most pervasive malignancies affecting the female population. Despite progressive improvements in diagnostic and therapeutic technologies, leading to an increased detection of early stage BCs, locally advanced breast cancer (LABC) persists as a significant cl...

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Bibliographic Details
Published in:Medicinal research reviews 2024-03, Vol.44 (2), p.606-631
Main Authors: Kong, Xiangyi, Song, Jiarui, Gao, Peng, Gao, Ran, Zhang, Lin, Fang, Yi, Wang, Yipeng, Gao, Jidong, Wang, Jing
Format: Article
Language:English
Subjects:
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - radiotherapy
Female
Humans
locally advanced breast cancer
mastectomy
Medical diagnosis
Metastasis
neoadjuvant radiotherapy
Neoadjuvant Therapy
Postoperative period
Quality of Life
Radiation therapy
review
Survival analysis
Womens health
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Summary:Breast cancer (BC) constitutes one of the most pervasive malignancies affecting the female population. Despite progressive improvements in diagnostic and therapeutic technologies, leading to an increased detection of early stage BCs, locally advanced breast cancer (LABC) persists as a significant clinical challenge. Owing to its poor overall survival (OS) rate, elevated recurrence rate, and high potential for distant metastasis, LABC prominently impacts the comprehensive efficacy of BC treatments. Radiotherapy, encompassing preoperative, intraoperative, and postoperative modalities, is acknowledged as an effective strategy for mitigating BC metastasis and enhancing survival rates among patients. Nevertheless, the domain of preoperative neoadjuvant radiotherapy (NART) remains conspicuously underexplored in clinical studies. Available research suggests that NART can induce tumor volume reduction, provoke fibrotic changes in tumor and adjacent normal tissues, thereby mitigating intraoperative cancer propagation and enhancing the quality of life for LABC patients. This manuscript seeks to provide a review of contemporary research pertaining to LABC and its preoperative radiotherapy.
ISSN:0198-6325
1098-1128
1098-1128
DOI:10.1002/med.21998