TGF-β, EMT, and resistance to anti-cancer treatment

Transforming growth factor-β (TGF-β) signaling regulates cell-specific programs involved in embryonic development, wound-healing, and immune homeostasis. Yet, during tumor progression, these TGF-β-mediated programs are altered, leading to epithelial cell plasticity and a reprogramming of epithelial...

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Bibliographic Details
Published in:Seminars in cancer biology 2023-12, Vol.97, p.1-11
Main Authors: Wang, Xuecong, Eichhorn, Pieter Johan Adam, Thiery, Jean Paul
Format: Article
Language:English
Subjects:
Carcinoma
Cell Line, Tumor
Epithelial Cells
Epithelial-Mesenchymal Transition - genetics
Humans
Signal Transduction
Transforming Growth Factor beta
Tumor Microenvironment
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Summary:Transforming growth factor-β (TGF-β) signaling regulates cell-specific programs involved in embryonic development, wound-healing, and immune homeostasis. Yet, during tumor progression, these TGF-β-mediated programs are altered, leading to epithelial cell plasticity and a reprogramming of epithelial cells into mesenchymal lineages through epithelial-to-mesenchymal transition (EMT), a critical developmental program in morphogenesis and organogenesis. These changes, in turn, lead to enhanced carcinoma cell invasion, metastasis, immune cell differentiation, immune evasion, and chemotherapy resistance. Here, we discuss EMT as one of the critical programs associated with carcinoma cell plasticity and the influence exerted by TGF-β on carcinoma status and function. We further explore the composition of carcinoma and other cell populations within the tumor microenvironment, and consider the relevant outcomes related to the programs associated with cancer treatment resistance.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2023.10.004