Identification of areas of the brain activated by active stimulation in hairless skin

• Published in: Behavioural brain research 2024-02, Vol.458, p.114758-114758, Article 114758
• Main Authors: Sasaki, Kei, Sakurai, Noriko, Yuguchi, Yukina, Kasai, Satoshi, Kodama, Naoki
• Format: Article
• Language: English
• Subjects: Brain - physiology; Emotions - physiology; Humans; Magnetic Resonance Imaging - methods; Physical Stimulation - methods; Skin; Touch - physiology; Touch Perception - physiology
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/j.bbr.2023.114758

In the past few decades, neuroscientists have studied the physiological basis of pleasant touch. Unmyelinated low-threshold mechanoreceptors are central to the study of the physiological basis of pleasant touch. Research on pleasant stimuli has mostly focused on passive stimuli, and the brain activation sites for active pleasant stimuli are not clear. Therefore, the purpose of this study was to identify brain activation sites during active pleasant stimulation of hairless skin using functional magnetic resonance imaging. Forty-two healthy subjects aged 19 years or older were asked to actively grasp in five stimulus tasks. The comfort and sensations that occurred during the tasks were investigated using a questionnaire. Significant activation was found in the middle frontal gyrus when the hair ball and slime ball were grasped, while there was significant activation in the amygdala when grasping a squeeze ball compared to the tennis ball. In a questionnaire survey of the subjects, there was a significant difference in the comfort score between the tennis ball and the squeeze ball, but no significant correlation was found between the comfort scores and the brain sites of activation. Therefore, although active stimulation with the squeeze ball significantly activated the amygdala, it was not clear that the amygdala was significantly activated by active pleasant stimulation. In the future, it will be necessary to investigate the texture of the squeeze ball in more detail, and to increase the number of subjects for further study.