Progressive Multifocal Leukoencephalopathy in Systemic Lupus Erythematosus: A Consequence of Patient-Intrinsic or -Extrinsic Factors?

Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system (CNS) caused by reactivation of the polyomavirus JC (JCV) typically in immunocompromised individuals. The risk of PML among rheumatic diseases may be higher for systemic lupus erythematos...

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Bibliographic Details
Published in:Journal of clinical medicine 2023-11, Vol.12 (21), p.6945
Main Authors: Emmanouilidou, Evgenia, Kosmara, Despoina, Papadaki, Efrosini, Mastorodemos, Vasileios, Constantoulakis, Pantelis, Repa, Argyro, Christopoulou, Georgia, Kalpadakis, Christina, Avgoustidis, Nestor, Thomas, Konstantinos, Boumpas, Dimitrios, Sidiropoulos, Prodromos, Bertsias, George
Format: Article
Language:English
Subjects:
Ataxia
Bioinformatics
Blood
Bone marrow
Care and treatment
Clinical medicine
Complications and side effects
Diagnosis
Encephalitis
Genomes
Health aspects
Immune system
Immunocompromised host
Immunotherapy
Infections
Leukoencephalopathy, Progressive multifocal
Lupus
Magnetic resonance imaging
Patient outcomes
Patients
Risk factors
Systemic lupus erythematosus
Viral infections
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Summary:Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system (CNS) caused by reactivation of the polyomavirus JC (JCV) typically in immunocompromised individuals. The risk of PML among rheumatic diseases may be higher for systemic lupus erythematosus (SLE), without, however, a clear association with the type and intensity of background therapy. We present the development and outcome of PML in a 32-year-old female lupus patient under mild immunosuppressive treatment, yet with marked B-cell lymphopenia in the peripheral blood and bone marrow (
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12216945