Prognostic impact of early ctDNA dynamics during chemotherapy of metastatic cancer

Clinical utility of the dynamics of ctDNA is sparse. This study aimed at evaluating the prognostic impact of early ctDNA dynamics in patients with metastatic cancer treated with chemotherapy. The ctDNA dynamics were evaluated in 595 patients with metastatic cancer using droplet digital PCR. Patients...

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Bibliographic Details
Published in:Future oncology (London, England) England), 2023-11, Vol.19 (35), p.2361-2367
Main Authors: Faaborg, Louise, Andersen, Rikke Fredslund, Wen, Sara WC, Thomsen, Caroline B, Raunkilde, Louise, Hansen, Torben Frøstrup, Jensen, Lars Henrik, Steffensen, Karina Dahl, Jakobsen, Anders
Format: Article
Language:English
Subjects:
ctDNA
droplet digital PCR
dynamics
methylation
prognosis
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Summary:Clinical utility of the dynamics of ctDNA is sparse. This study aimed at evaluating the prognostic impact of early ctDNA dynamics in patients with metastatic cancer treated with chemotherapy. The ctDNA dynamics were evaluated in 595 patients with metastatic cancer using droplet digital PCR. Patients with an increase in ctDNA after one treatment cycle (n = 73; 12.2%) had an overall survival of 5.6 months compared with 8.6 months in patients with stable or decreasing ctDNA (n = 328; 55.1%) and 21.0 months in patients with undetectable ctDNA (p 
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2023-0111