Revolutionizing colorectal cancer treatment: unleashing the potential of miRNAs in targeting cancer stem cells

Colorectal cancer (CRC) is a significant contributor to cancer mortality worldwide, and the presence of cancer stem cells (CSC) represents a major challenge for achieving effective treatment. miRNAs have emerged as critical regulators of gene expression, and recent studies have highlighted their rol...

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Bibliographic Details
Published in:Future oncology (London, England) England), 2023-11, Vol.19 (35), p.2369-2382
Main Authors: Osei, George Yiadom, Adu-Amankwaah, Joseph, Koomson, Selina, Beletaa, Solomon, Ahmad, Muhammad Khairi, Asiamah, Emmanuel Akomanin, Smith-Togobo, Cecilia, Abdul Razak, Siti Razila
Format: Article
Language:English
Subjects:
cancer stem cells
colorectal cancer
miRNA
miRNA delivery
miRNA-based therapies
stemness
targeted therapy
therapy resistance
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Summary:Colorectal cancer (CRC) is a significant contributor to cancer mortality worldwide, and the presence of cancer stem cells (CSC) represents a major challenge for achieving effective treatment. miRNAs have emerged as critical regulators of gene expression, and recent studies have highlighted their role in regulating stemness and therapeutic resistance in CRC stem cells. This review highlights the mechanisms of CSC development, therapy resistance and the potential of miRNAs as therapeutic targets for CRC. It emphasizes the promise of miRNAs as a novel approach to CRC treatment and calls for further research to explore effective miRNA-based therapies and strategies for delivering miRNAs to CSCs .
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2023-0426