Characteristics and outcomes of COVID‐19 in Chinese immune thrombocytopenia patients: A prospective cohort study

• Published in: British journal of haematology 2024-04, Vol.204 (4), p.1207-1218
• Main Authors: Chen, Yunfei, Liu, Jiaying, Shao, Shuai, Song, Zhen, Ma, Yueshen, Tuo, Yuanyuan, Fang, Lijun, Xu, Yanmei, Xu, Bingqi, Gu, Wenjing, Cao, Xuan, Chen, Jia, Yang, Yu, Wang, Panjing, Zhang, Jing, Xu, Yuan, Yu, Dandan, Hou, Pengxiao, Meng, Ke, Li, Zhirong, Liu, Guanyu, Qu, Xinmiao, Ji, Lulu, Yang, Renchi, Zhang, Lei
• Format: Article
• Language: English
• Subjects: Cohort analysis; Comorbidity; Coronaviruses; COVID-19; Hematological diseases; Idiopathic thrombocytopenic purpura; Immune system; immune thrombocytopenia; Immunosuppressive agents; Pneumonia; Risk factors; Splenectomy; Thrombocytopenia; Thrombopoietin
• ISSN: 0007-1048; 1365-2141
• DOI: 10.1111/bjh.19198

Summary The coronavirus disease 2019 (COVID‐19) pandemic has a significant impact on the immune system. This is the first and largest study on pre‐existing immune thrombocytopenia (ITP) patients infected with COVID‐19 in China. We prospectively collected ITP patients infected with COVID‐19 enrolled in the National Longitudinal Cohort of Hematological Diseases (NICHE, NCT04645199) and followed up for at least 1 month after infection. One thousand and one hundred forty‐eight pre‐existing ITP patients were included. Two hundred and twelve (18.5%) patients showed a decrease in the platelet (PLT) count after infection. Forty‐seven (4.1%) patients were diagnosed with pneumonia. Risk factors for a decrease in the PLT count included baseline PLT count