Phase-separation behaviour of RNAs

Ribonucleoprotein granules are ubiquitous in living organisms with the protein and RNA components having distinct roles. In the absence of proteins, RNAs are shown to undergo phase separation upon heating. This transition is driven by desolvation entropy and ion-mediated crosslinking and is tuned by...

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Bibliographic Details
Published in:Nature chemistry 2023-12, Vol.15 (12), p.1660-1661
Format: Article
Language:English
Subjects:
631/57/2272/951
639/638/455/953
Analytical Chemistry
Bases (nucleic acids)
Biochemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Crosslinking
Entropy
Heat
Inorganic Chemistry
Organic Chemistry
Phase separation
Phase transitions
Physical Chemistry
Polymers
Proteins
Research Briefing
Temperature
Thermal cycling
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Summary:Ribonucleoprotein granules are ubiquitous in living organisms with the protein and RNA components having distinct roles. In the absence of proteins, RNAs are shown to undergo phase separation upon heating. This transition is driven by desolvation entropy and ion-mediated crosslinking and is tuned by the chemical specificity of the RNA nucleobases.
ISSN:1755-4330
1755-4349
DOI:10.1038/s41557-023-01359-y