Short‐latency reaction time and accuracy are impaired in patients with cirrhosis: An international multicenter retrospective study

Aim The inability to quickly react to an external event can lead to an increased risk for accidents (e.g., falls, car crashes) in patients with cirrhosis. The aim of this study was to determine whether a novel clinically feasible measure of simple reaction time (SRT) and reaction accuracy (RA)—a go/...

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Published in:Geriatrics & gerontology international 2024-01, Vol.24 (1), p.25-31
Main Authors: Miwa, Takao, Richardson, James K., Murphy, Susan L., Ellmers, Toby J., Miwa, Yoshiyuki, Maeda, Teruo, Hanai, Tatsunori, Shimizu, Masahito
Format: Article
Language:English
Subjects:
Cognitive ability
covert hepatic encephalopathy
driving ability
falls
Liver cirrhosis
minimal hepatic encephalopathy
Regression analysis
Traffic accidents & safety
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container_issue 1
container_start_page 25
container_title Geriatrics & gerontology international
container_volume 24
creator Miwa, Takao
Richardson, James K.
Murphy, Susan L.
Ellmers, Toby J.
Miwa, Yoshiyuki
Maeda, Teruo
Hanai, Tatsunori
Shimizu, Masahito
description Aim The inability to quickly react to an external event can lead to an increased risk for accidents (e.g., falls, car crashes) in patients with cirrhosis. The aim of this study was to determine whether a novel clinically feasible measure of simple reaction time (SRT) and reaction accuracy (RA)—a go/no‐go task occurring within 400 ms—could differentiate patients with cirrhosis from controls. Methods This retrospective study included 160 patients with cirrhosis and 160 controls assessed between January 2010 and October 2022. SRT and RA were evaluated using a ruler drop paradigm and compared using propensity score matching. Factors distinguishing patients with cirrhosis from controls were assessed using logistic regression and receiver operating characteristics curve (ROC) analyses. Results Propensity score matching identified 112 participants in each group with comparable baseline characteristics. As compared with controls, patients with cirrhosis exhibited significantly prolonged SRT (200 vs. 174 ms; P 
doi_str_mv 10.1111/ggi.14742
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The aim of this study was to determine whether a novel clinically feasible measure of simple reaction time (SRT) and reaction accuracy (RA)—a go/no‐go task occurring within 400 ms—could differentiate patients with cirrhosis from controls. Methods This retrospective study included 160 patients with cirrhosis and 160 controls assessed between January 2010 and October 2022. SRT and RA were evaluated using a ruler drop paradigm and compared using propensity score matching. Factors distinguishing patients with cirrhosis from controls were assessed using logistic regression and receiver operating characteristics curve (ROC) analyses. Results Propensity score matching identified 112 participants in each group with comparable baseline characteristics. As compared with controls, patients with cirrhosis exhibited significantly prolonged SRT (200 vs. 174 ms; P &lt; 0.001) and diminished total RA (63% vs. 73%; P &lt; 0.001). After adjustment for confounding factors, SRT and RA independently identified patients with cirrhosis. ROC analyses showed that SRT more effectively identified patients with cirrhosis than did the number‐connection test/trail‐making test‐B (area under the curve, 0.87 vs. 0.60; P &lt; 0.001). Conclusions Patients with cirrhosis demonstrated impairments in short‐latency cognitive function. Given that SRT and RA are associated with balance, falls, and response to perturbation, these parameters may present a task‐specific method to identify patients with cirrhosis at high risk of falls and motor vehicle crashes. Geriatr Gerontol Int 2024; 24: 25–31. This study aimed to compare short‐latency cognitive function using a measure of simple reaction time (SRT) and reaction accuracy (RA)—a go/no‐go task occurring within 400 ms—between patients with cirrhosis and controls. After propensity score matching, patients with cirrhosis exhibited a significantly prolonged SRT and diminished total RA accuracy. Given that SRT and RA are associated with responses to perturbation, evaluating short‐latency cognitive function may be a task‐specific method to identify patients with cirrhosis at high risk of falls and motor vehicle crashes.</description><identifier>ISSN: 1444-1586</identifier><identifier>EISSN: 1447-0594</identifier><identifier>DOI: 10.1111/ggi.14742</identifier><identifier>PMID: 37973613</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley &amp; Sons Australia, Ltd</publisher><subject>Cognitive ability ; covert hepatic encephalopathy ; driving ability ; falls ; Liver cirrhosis ; minimal hepatic encephalopathy ; Regression analysis ; Traffic accidents &amp; safety</subject><ispartof>Geriatrics &amp; gerontology international, 2024-01, Vol.24 (1), p.25-31</ispartof><rights>2023 Japan Geriatrics Society.</rights><rights>2024 Japan Geriatrics Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3882-54ea647dbac2260b902b5a98c66c7cceff7a29f4e66a344209ca096f951ff33e3</citedby><cites>FETCH-LOGICAL-c3882-54ea647dbac2260b902b5a98c66c7cceff7a29f4e66a344209ca096f951ff33e3</cites><orcidid>0000-0002-6373-260X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37973613$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miwa, Takao</creatorcontrib><creatorcontrib>Richardson, James K.</creatorcontrib><creatorcontrib>Murphy, Susan L.</creatorcontrib><creatorcontrib>Ellmers, Toby J.</creatorcontrib><creatorcontrib>Miwa, Yoshiyuki</creatorcontrib><creatorcontrib>Maeda, Teruo</creatorcontrib><creatorcontrib>Hanai, Tatsunori</creatorcontrib><creatorcontrib>Shimizu, Masahito</creatorcontrib><title>Short‐latency reaction time and accuracy are impaired in patients with cirrhosis: An international multicenter retrospective study</title><title>Geriatrics &amp; gerontology international</title><addtitle>Geriatr Gerontol Int</addtitle><description>Aim The inability to quickly react to an external event can lead to an increased risk for accidents (e.g., falls, car crashes) in patients with cirrhosis. The aim of this study was to determine whether a novel clinically feasible measure of simple reaction time (SRT) and reaction accuracy (RA)—a go/no‐go task occurring within 400 ms—could differentiate patients with cirrhosis from controls. Methods This retrospective study included 160 patients with cirrhosis and 160 controls assessed between January 2010 and October 2022. SRT and RA were evaluated using a ruler drop paradigm and compared using propensity score matching. Factors distinguishing patients with cirrhosis from controls were assessed using logistic regression and receiver operating characteristics curve (ROC) analyses. Results Propensity score matching identified 112 participants in each group with comparable baseline characteristics. As compared with controls, patients with cirrhosis exhibited significantly prolonged SRT (200 vs. 174 ms; P &lt; 0.001) and diminished total RA (63% vs. 73%; P &lt; 0.001). After adjustment for confounding factors, SRT and RA independently identified patients with cirrhosis. ROC analyses showed that SRT more effectively identified patients with cirrhosis than did the number‐connection test/trail‐making test‐B (area under the curve, 0.87 vs. 0.60; P &lt; 0.001). Conclusions Patients with cirrhosis demonstrated impairments in short‐latency cognitive function. Given that SRT and RA are associated with balance, falls, and response to perturbation, these parameters may present a task‐specific method to identify patients with cirrhosis at high risk of falls and motor vehicle crashes. Geriatr Gerontol Int 2024; 24: 25–31. This study aimed to compare short‐latency cognitive function using a measure of simple reaction time (SRT) and reaction accuracy (RA)—a go/no‐go task occurring within 400 ms—between patients with cirrhosis and controls. After propensity score matching, patients with cirrhosis exhibited a significantly prolonged SRT and diminished total RA accuracy. Given that SRT and RA are associated with responses to perturbation, evaluating short‐latency cognitive function may be a task‐specific method to identify patients with cirrhosis at high risk of falls and motor vehicle crashes.</description><subject>Cognitive ability</subject><subject>covert hepatic encephalopathy</subject><subject>driving ability</subject><subject>falls</subject><subject>Liver cirrhosis</subject><subject>minimal hepatic encephalopathy</subject><subject>Regression analysis</subject><subject>Traffic accidents &amp; safety</subject><issn>1444-1586</issn><issn>1447-0594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kb9OHDEQh60IFOCgyAtEltIkxXL22muv6RBKDiQkCqBezXlnOaP9h-0FXZciD5BnzJPg44AiEm7Gmvn0jUY_Qr5wdszTm9_duWMutcw_kX0upc5YYeTOy19mvCjVHjkI4Z4xrg3nn8me0EYLxcU--XO9Gnz89_tvCxF7u6YewUY39DS6Din0NQVrJw9pBB6p60ZwHmvqejpCdNjHQJ9cXFHrvF8NwYUTetqncUTfw8YELe2mNjqLm15aEP0QRkxbHpGGONXrQ7LbQBvw6LXOyO2vnzdn59nl1eLi7PQys6Is86yQCErqegk2zxVbGpYvCzClVcpqa7FpNOSmkagUCClzZiwwoxpT8KYRAsWMfN96Rz88TBhi1blgsW2hx2EKVV4argumVZHQb_-h98OUDmoTZZgRRmllEvVjS9l0UvDYVKN3Hfh1xVm1iaZK0VQv0ST266txWnZYv5NvWSRgvgWeXIvrj03VYnGxVT4Dv_qbuA</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Miwa, Takao</creator><creator>Richardson, James K.</creator><creator>Murphy, Susan L.</creator><creator>Ellmers, Toby J.</creator><creator>Miwa, Yoshiyuki</creator><creator>Maeda, Teruo</creator><creator>Hanai, Tatsunori</creator><creator>Shimizu, Masahito</creator><general>John Wiley &amp; Sons Australia, Ltd</general><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6373-260X</orcidid></search><sort><creationdate>202401</creationdate><title>Short‐latency reaction time and accuracy are impaired in patients with cirrhosis: An international multicenter retrospective study</title><author>Miwa, Takao ; Richardson, James K. ; Murphy, Susan L. ; Ellmers, Toby J. ; Miwa, Yoshiyuki ; Maeda, Teruo ; Hanai, Tatsunori ; Shimizu, Masahito</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3882-54ea647dbac2260b902b5a98c66c7cceff7a29f4e66a344209ca096f951ff33e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cognitive ability</topic><topic>covert hepatic encephalopathy</topic><topic>driving ability</topic><topic>falls</topic><topic>Liver cirrhosis</topic><topic>minimal hepatic encephalopathy</topic><topic>Regression analysis</topic><topic>Traffic accidents &amp; safety</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miwa, Takao</creatorcontrib><creatorcontrib>Richardson, James K.</creatorcontrib><creatorcontrib>Murphy, Susan L.</creatorcontrib><creatorcontrib>Ellmers, Toby J.</creatorcontrib><creatorcontrib>Miwa, Yoshiyuki</creatorcontrib><creatorcontrib>Maeda, Teruo</creatorcontrib><creatorcontrib>Hanai, Tatsunori</creatorcontrib><creatorcontrib>Shimizu, Masahito</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Geriatrics &amp; gerontology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miwa, Takao</au><au>Richardson, James K.</au><au>Murphy, Susan L.</au><au>Ellmers, Toby J.</au><au>Miwa, Yoshiyuki</au><au>Maeda, Teruo</au><au>Hanai, Tatsunori</au><au>Shimizu, Masahito</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short‐latency reaction time and accuracy are impaired in patients with cirrhosis: An international multicenter retrospective study</atitle><jtitle>Geriatrics &amp; gerontology international</jtitle><addtitle>Geriatr Gerontol Int</addtitle><date>2024-01</date><risdate>2024</risdate><volume>24</volume><issue>1</issue><spage>25</spage><epage>31</epage><pages>25-31</pages><issn>1444-1586</issn><eissn>1447-0594</eissn><abstract>Aim The inability to quickly react to an external event can lead to an increased risk for accidents (e.g., falls, car crashes) in patients with cirrhosis. The aim of this study was to determine whether a novel clinically feasible measure of simple reaction time (SRT) and reaction accuracy (RA)—a go/no‐go task occurring within 400 ms—could differentiate patients with cirrhosis from controls. Methods This retrospective study included 160 patients with cirrhosis and 160 controls assessed between January 2010 and October 2022. SRT and RA were evaluated using a ruler drop paradigm and compared using propensity score matching. Factors distinguishing patients with cirrhosis from controls were assessed using logistic regression and receiver operating characteristics curve (ROC) analyses. Results Propensity score matching identified 112 participants in each group with comparable baseline characteristics. As compared with controls, patients with cirrhosis exhibited significantly prolonged SRT (200 vs. 174 ms; P &lt; 0.001) and diminished total RA (63% vs. 73%; P &lt; 0.001). After adjustment for confounding factors, SRT and RA independently identified patients with cirrhosis. ROC analyses showed that SRT more effectively identified patients with cirrhosis than did the number‐connection test/trail‐making test‐B (area under the curve, 0.87 vs. 0.60; P &lt; 0.001). Conclusions Patients with cirrhosis demonstrated impairments in short‐latency cognitive function. Given that SRT and RA are associated with balance, falls, and response to perturbation, these parameters may present a task‐specific method to identify patients with cirrhosis at high risk of falls and motor vehicle crashes. Geriatr Gerontol Int 2024; 24: 25–31. This study aimed to compare short‐latency cognitive function using a measure of simple reaction time (SRT) and reaction accuracy (RA)—a go/no‐go task occurring within 400 ms—between patients with cirrhosis and controls. After propensity score matching, patients with cirrhosis exhibited a significantly prolonged SRT and diminished total RA accuracy. Given that SRT and RA are associated with responses to perturbation, evaluating short‐latency cognitive function may be a task‐specific method to identify patients with cirrhosis at high risk of falls and motor vehicle crashes.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley &amp; Sons Australia, Ltd</pub><pmid>37973613</pmid><doi>10.1111/ggi.14742</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6373-260X</orcidid><oa>free_for_read</oa></addata></record>
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subjects Cognitive ability
covert hepatic encephalopathy
driving ability
falls
Liver cirrhosis
minimal hepatic encephalopathy
Regression analysis
Traffic accidents & safety
title Short‐latency reaction time and accuracy are impaired in patients with cirrhosis: An international multicenter retrospective study
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