A non-pregnant woman with elevated beta-HCG: A rare case of ovarian seminoma

• Published in: International journal of surgery case reports 2023, Vol.113, p.109028-109028
• Main Authors: Mraihi, Fathi, Basly, Jihene, Ghali, Zeineb, Mezni, Amani, Amami, Malek, Chelli, Dalenda
• Format: Report
• Language: English
• ISSN: 2210-2612; 2210-2612
• DOI: 10.1016/j.ijscr.2023.109028

INTRODUCTIONOvarian seminoma is a rare germ cell tumor that typically affects young women. Early diagnosis of malignant tumors, although difficult due to mild symptoms, is crucial for a better prognosis. Here we report the case of a 15-year-old female patient with a large malignant ovarian dysgerminoma to provide a comprehensive overview of the diagnosis and management of this pathology and to help practitioners make an early diagnosis.CASE PRESENTATIONA 15-year-old patient with no significant past medical history presented to the Obstetrics and Gynecology emergency D in Tunisia with subacute abdominal pain, fever, and unexplained weight loss. Diagnostic evaluation revealed a large, solid ovarian mass with elevated CA-125 levels, and the patient subsequently underwent right adnexectomy with peritoneal cytology. Histopathological analysis confirmed the diagnosis of dysgerminoma with peritoneal involvement, resulting in a FIGO IC and TNM T1C classification, and the patient received fertility-sparing polychemotherapy with satisfactory progression.DISCUSSIONOvarian seminoma mainly affects young women and can be associated with a variety of risk factors. Clinical signs are variable and can be difficult to detect at an early stage. Imaging techniques can help with diagnosis. Tumor markers may be elevated, but histological confirmation is needed. Treatment usually consists of a combination of surgery and chemotherapy, with good long-term survival rates.CONCLUSIONSeminomas are rare tumors and early detection is crucial for a better prognosis. This requires close attention to risk factors and regular gynecological examinations from an early age in patients with these risk factors.