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Predictors of periapical bone healing associated with teeth having large periapical lesions following nonsurgical root canal treatment or retreatment: A cone beam computed tomography‐based retrospective study
Aim Several factors influence the condition of the periapical tissues associated with root filled teeth. The primary objective of this study was to retrospectively evaluate the extent and speed of bone healing of large periapical lesions associated with nonsurgical root canal treatment or retreatmen...
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Published in: | International endodontic journal 2024-01, Vol.57 (1), p.23-36 |
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creator | Mosquera‐Barreiro, Carolina Ruíz‐Piñón, Manuel Sans, Francesc Abella Nagendrababu, Venkateshbabu Vinothkumar, Thilla Sekar Martín‐González, Jenifer Martín‐Biedma, Benjamín Castelo‐Baz, Pablo |
description | Aim
Several factors influence the condition of the periapical tissues associated with root filled teeth. The primary objective of this study was to retrospectively evaluate the extent and speed of bone healing of large periapical lesions associated with nonsurgical root canal treatment or retreatment. The secondary objective was to analyse the relationship between the time to complete healing when analysed using cone beam computed tomography (CBCT) and other possible predictors that affect healing.
Methodology
Seventy‐nine patients were treated during the years 2013–2020 with large periapical lesions of endodontic origin (10–15 mm) as observed on intraoral periapical radiographs (IOPAR) were included. IOPAR and CBCT were available before treatment and during the follow‐up (IOPAR every 6 months and CBCT every 12 months). The volume of periapical lesions was calculated by OsiriX Lite software. Variables such as initial volume of the lesion, age, gender, type of treatment or type of root canal filling were compared to identify the differences between healed and unhealed lesions. Pearson's Chi‐square test was used for categorical variables, the t‐test for age and the Wilcoxon test for initial volume of the lesion. The association between time to healing and the variables was assessed using univariate analysis and multivariate analysis. The Wilcoxon test was used to observe the association of healing time with categorical variables and the correlation index was measured with the quantitative variables.
Results
Of the 79 cases analysed, 60 lesions (76%) were completely healed as verified by CBCT in a mean healing time of 19 months, of which 60% healed fully between 12 and 18 months. Increase in age of patient and larger initial volume of the lesion were associated with a significantly longer healing time (p .05).
Conclusions
Clinicians should be aware that periapical lesions in older patients and larger areas of bone loss take longer to heal. CBCT monitoring of large periapical lesions is critical and it can help clinicians in the decision‐making process. |
doi_str_mv | 10.1111/iej.13993 |
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Several factors influence the condition of the periapical tissues associated with root filled teeth. The primary objective of this study was to retrospectively evaluate the extent and speed of bone healing of large periapical lesions associated with nonsurgical root canal treatment or retreatment. The secondary objective was to analyse the relationship between the time to complete healing when analysed using cone beam computed tomography (CBCT) and other possible predictors that affect healing.
Methodology
Seventy‐nine patients were treated during the years 2013–2020 with large periapical lesions of endodontic origin (10–15 mm) as observed on intraoral periapical radiographs (IOPAR) were included. IOPAR and CBCT were available before treatment and during the follow‐up (IOPAR every 6 months and CBCT every 12 months). The volume of periapical lesions was calculated by OsiriX Lite software. Variables such as initial volume of the lesion, age, gender, type of treatment or type of root canal filling were compared to identify the differences between healed and unhealed lesions. Pearson's Chi‐square test was used for categorical variables, the t‐test for age and the Wilcoxon test for initial volume of the lesion. The association between time to healing and the variables was assessed using univariate analysis and multivariate analysis. The Wilcoxon test was used to observe the association of healing time with categorical variables and the correlation index was measured with the quantitative variables.
Results
Of the 79 cases analysed, 60 lesions (76%) were completely healed as verified by CBCT in a mean healing time of 19 months, of which 60% healed fully between 12 and 18 months. Increase in age of patient and larger initial volume of the lesion were associated with a significantly longer healing time (p < .001). Gender, filling material and type of treatment did not have a significant effect on the healing process (p > .05).
Conclusions
Clinicians should be aware that periapical lesions in older patients and larger areas of bone loss take longer to heal. CBCT monitoring of large periapical lesions is critical and it can help clinicians in the decision‐making process.</description><identifier>ISSN: 0143-2885</identifier><identifier>EISSN: 1365-2591</identifier><identifier>DOI: 10.1111/iej.13993</identifier><identifier>PMID: 37974453</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Age ; Bone healing ; Bone loss ; Computed tomography ; cone beam computed tomography ; Decision making ; Endodontics ; follow‐up ; Gender ; Lesions ; Multivariate analysis ; periapical healing ; root canal treatment ; Root canals ; Teeth ; Tomography</subject><ispartof>International endodontic journal, 2024-01, Vol.57 (1), p.23-36</ispartof><rights>2023 The Authors. published by John Wiley & Sons Ltd on behalf of British Endodontic Society.</rights><rights>2023 The Authors. International Endodontic Journal published by John Wiley & Sons Ltd on behalf of British Endodontic Society.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3483-63037183d43fb3dce0ef381c84e97c0df6d509d304462f12c47482fe2faeb4073</cites><orcidid>0000-0001-9282-133X ; 0000-0002-4297-4220 ; 0000-0003-3031-5532 ; 0000-0002-3500-3039 ; 0000-0002-9110-3173 ; 0000-0002-2032-4681 ; 0000-0003-3783-3156 ; 0000-0001-9798-3872</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37974453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mosquera‐Barreiro, Carolina</creatorcontrib><creatorcontrib>Ruíz‐Piñón, Manuel</creatorcontrib><creatorcontrib>Sans, Francesc Abella</creatorcontrib><creatorcontrib>Nagendrababu, Venkateshbabu</creatorcontrib><creatorcontrib>Vinothkumar, Thilla Sekar</creatorcontrib><creatorcontrib>Martín‐González, Jenifer</creatorcontrib><creatorcontrib>Martín‐Biedma, Benjamín</creatorcontrib><creatorcontrib>Castelo‐Baz, Pablo</creatorcontrib><title>Predictors of periapical bone healing associated with teeth having large periapical lesions following nonsurgical root canal treatment or retreatment: A cone beam computed tomography‐based retrospective study</title><title>International endodontic journal</title><addtitle>Int Endod J</addtitle><description>Aim
Several factors influence the condition of the periapical tissues associated with root filled teeth. The primary objective of this study was to retrospectively evaluate the extent and speed of bone healing of large periapical lesions associated with nonsurgical root canal treatment or retreatment. The secondary objective was to analyse the relationship between the time to complete healing when analysed using cone beam computed tomography (CBCT) and other possible predictors that affect healing.
Methodology
Seventy‐nine patients were treated during the years 2013–2020 with large periapical lesions of endodontic origin (10–15 mm) as observed on intraoral periapical radiographs (IOPAR) were included. IOPAR and CBCT were available before treatment and during the follow‐up (IOPAR every 6 months and CBCT every 12 months). The volume of periapical lesions was calculated by OsiriX Lite software. Variables such as initial volume of the lesion, age, gender, type of treatment or type of root canal filling were compared to identify the differences between healed and unhealed lesions. Pearson's Chi‐square test was used for categorical variables, the t‐test for age and the Wilcoxon test for initial volume of the lesion. The association between time to healing and the variables was assessed using univariate analysis and multivariate analysis. The Wilcoxon test was used to observe the association of healing time with categorical variables and the correlation index was measured with the quantitative variables.
Results
Of the 79 cases analysed, 60 lesions (76%) were completely healed as verified by CBCT in a mean healing time of 19 months, of which 60% healed fully between 12 and 18 months. Increase in age of patient and larger initial volume of the lesion were associated with a significantly longer healing time (p < .001). Gender, filling material and type of treatment did not have a significant effect on the healing process (p > .05).
Conclusions
Clinicians should be aware that periapical lesions in older patients and larger areas of bone loss take longer to heal. CBCT monitoring of large periapical lesions is critical and it can help clinicians in the decision‐making process.</description><subject>Age</subject><subject>Bone healing</subject><subject>Bone loss</subject><subject>Computed tomography</subject><subject>cone beam computed tomography</subject><subject>Decision making</subject><subject>Endodontics</subject><subject>follow‐up</subject><subject>Gender</subject><subject>Lesions</subject><subject>Multivariate analysis</subject><subject>periapical healing</subject><subject>root canal treatment</subject><subject>Root canals</subject><subject>Teeth</subject><subject>Tomography</subject><issn>0143-2885</issn><issn>1365-2591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp1kcFu1DAQhi0EotvCgRdAlri0h7R27CQ2t6oqUFQJDnCOHGe865UTB9vpam88As_GI_AkON1SISR8sGc83_wj-0foFSXnNK8LC9tzyqRkT9CKsroqykrSp2hFKGdFKUR1hI5j3BJCKsLoc3TEGtlwXrEV-vk5QG918iFib_AEwarJauVw50fAG1DOjmusYvTaqgQ93tm0wQkg7xt1txSdCmv4u9VBtH6M2Hjn_G5BxpzOYX1fDd4nrNWYwxRApQHGhH3AAR7Tt_gS62V-B2rI0TDNy-jkB78Oatrsf33_0amYr5YmHyfQyd4Bjmnu9y_QM6NchJcP5wn6-u76y9WH4vbT-5ury9tCMy5YUTPCGipYz5npWK-BgGGCasFBNpr0pu4rIntGOK9LQ0vNGy5KA6VR0HHSsBN0etCdgv82Q0ztYKMG59QIfo5tKSRtKi4qmtE3_6BbP4f8A5mS2RUha1pn6uxA6fykGMC0U7CDCvuWknYxus1Gt_dGZ_b1g-LcDdA_kn-czcDFAdhZB_v_K7U31x8Pkr8B9sa45g</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Mosquera‐Barreiro, Carolina</creator><creator>Ruíz‐Piñón, Manuel</creator><creator>Sans, Francesc Abella</creator><creator>Nagendrababu, Venkateshbabu</creator><creator>Vinothkumar, Thilla Sekar</creator><creator>Martín‐González, Jenifer</creator><creator>Martín‐Biedma, Benjamín</creator><creator>Castelo‐Baz, Pablo</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9282-133X</orcidid><orcidid>https://orcid.org/0000-0002-4297-4220</orcidid><orcidid>https://orcid.org/0000-0003-3031-5532</orcidid><orcidid>https://orcid.org/0000-0002-3500-3039</orcidid><orcidid>https://orcid.org/0000-0002-9110-3173</orcidid><orcidid>https://orcid.org/0000-0002-2032-4681</orcidid><orcidid>https://orcid.org/0000-0003-3783-3156</orcidid><orcidid>https://orcid.org/0000-0001-9798-3872</orcidid></search><sort><creationdate>202401</creationdate><title>Predictors of periapical bone healing associated with teeth having large periapical lesions following nonsurgical root canal treatment or retreatment: A cone beam computed tomography‐based retrospective study</title><author>Mosquera‐Barreiro, Carolina ; Ruíz‐Piñón, Manuel ; Sans, Francesc Abella ; Nagendrababu, Venkateshbabu ; Vinothkumar, Thilla Sekar ; Martín‐González, Jenifer ; Martín‐Biedma, Benjamín ; Castelo‐Baz, Pablo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3483-63037183d43fb3dce0ef381c84e97c0df6d509d304462f12c47482fe2faeb4073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Age</topic><topic>Bone healing</topic><topic>Bone loss</topic><topic>Computed tomography</topic><topic>cone beam computed tomography</topic><topic>Decision making</topic><topic>Endodontics</topic><topic>follow‐up</topic><topic>Gender</topic><topic>Lesions</topic><topic>Multivariate analysis</topic><topic>periapical healing</topic><topic>root canal treatment</topic><topic>Root canals</topic><topic>Teeth</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mosquera‐Barreiro, Carolina</creatorcontrib><creatorcontrib>Ruíz‐Piñón, Manuel</creatorcontrib><creatorcontrib>Sans, Francesc Abella</creatorcontrib><creatorcontrib>Nagendrababu, Venkateshbabu</creatorcontrib><creatorcontrib>Vinothkumar, Thilla Sekar</creatorcontrib><creatorcontrib>Martín‐González, Jenifer</creatorcontrib><creatorcontrib>Martín‐Biedma, Benjamín</creatorcontrib><creatorcontrib>Castelo‐Baz, Pablo</creatorcontrib><collection>Wiley_OA刊</collection><collection>Wiley Online Library Free Backfiles</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International endodontic journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mosquera‐Barreiro, Carolina</au><au>Ruíz‐Piñón, Manuel</au><au>Sans, Francesc Abella</au><au>Nagendrababu, Venkateshbabu</au><au>Vinothkumar, Thilla Sekar</au><au>Martín‐González, Jenifer</au><au>Martín‐Biedma, Benjamín</au><au>Castelo‐Baz, Pablo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of periapical bone healing associated with teeth having large periapical lesions following nonsurgical root canal treatment or retreatment: A cone beam computed tomography‐based retrospective study</atitle><jtitle>International endodontic journal</jtitle><addtitle>Int Endod J</addtitle><date>2024-01</date><risdate>2024</risdate><volume>57</volume><issue>1</issue><spage>23</spage><epage>36</epage><pages>23-36</pages><issn>0143-2885</issn><eissn>1365-2591</eissn><abstract>Aim
Several factors influence the condition of the periapical tissues associated with root filled teeth. The primary objective of this study was to retrospectively evaluate the extent and speed of bone healing of large periapical lesions associated with nonsurgical root canal treatment or retreatment. The secondary objective was to analyse the relationship between the time to complete healing when analysed using cone beam computed tomography (CBCT) and other possible predictors that affect healing.
Methodology
Seventy‐nine patients were treated during the years 2013–2020 with large periapical lesions of endodontic origin (10–15 mm) as observed on intraoral periapical radiographs (IOPAR) were included. IOPAR and CBCT were available before treatment and during the follow‐up (IOPAR every 6 months and CBCT every 12 months). The volume of periapical lesions was calculated by OsiriX Lite software. Variables such as initial volume of the lesion, age, gender, type of treatment or type of root canal filling were compared to identify the differences between healed and unhealed lesions. Pearson's Chi‐square test was used for categorical variables, the t‐test for age and the Wilcoxon test for initial volume of the lesion. The association between time to healing and the variables was assessed using univariate analysis and multivariate analysis. The Wilcoxon test was used to observe the association of healing time with categorical variables and the correlation index was measured with the quantitative variables.
Results
Of the 79 cases analysed, 60 lesions (76%) were completely healed as verified by CBCT in a mean healing time of 19 months, of which 60% healed fully between 12 and 18 months. Increase in age of patient and larger initial volume of the lesion were associated with a significantly longer healing time (p < .001). Gender, filling material and type of treatment did not have a significant effect on the healing process (p > .05).
Conclusions
Clinicians should be aware that periapical lesions in older patients and larger areas of bone loss take longer to heal. CBCT monitoring of large periapical lesions is critical and it can help clinicians in the decision‐making process.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37974453</pmid><doi>10.1111/iej.13993</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-9282-133X</orcidid><orcidid>https://orcid.org/0000-0002-4297-4220</orcidid><orcidid>https://orcid.org/0000-0003-3031-5532</orcidid><orcidid>https://orcid.org/0000-0002-3500-3039</orcidid><orcidid>https://orcid.org/0000-0002-9110-3173</orcidid><orcidid>https://orcid.org/0000-0002-2032-4681</orcidid><orcidid>https://orcid.org/0000-0003-3783-3156</orcidid><orcidid>https://orcid.org/0000-0001-9798-3872</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Age Bone healing Bone loss Computed tomography cone beam computed tomography Decision making Endodontics follow‐up Gender Lesions Multivariate analysis periapical healing root canal treatment Root canals Teeth Tomography |
title | Predictors of periapical bone healing associated with teeth having large periapical lesions following nonsurgical root canal treatment or retreatment: A cone beam computed tomography‐based retrospective study |
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