Ultrahighly Sensitive and Selective Glutathione Sensor Based on Carbon Dot-Functionalized Solution-Gate Graphene Transistor

A new type of carbon dot (CD)-functionalized solution-gated graphene transistor (SGGT) sensor was designed and fabricated for the highly sensitive and highly selective detection of glutathione (GSH). The CDs were synthesized via a one-step hydrothermal method using DL-thioctic acid and triethylenete...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2023-12, Vol.95 (48), p.17750-17758
Main Authors: Ren, Zhanpeng, Wang, Jianying, Xue, Chenglong, Deng, Minghua, Yu, Haiyang, Lin, Tianci, Zheng, Jiayuan, He, Rongxiang, Wang, Xianbao, Li, Jinhua
Format: Article
Language:English
Subjects:
Carbon
Carbon dots
Glutathione
Graphene
Graphite
Limit of Detection
Lipoic acid
Quantum Dots
Transistors
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Summary:A new type of carbon dot (CD)-functionalized solution-gated graphene transistor (SGGT) sensor was designed and fabricated for the highly sensitive and highly selective detection of glutathione (GSH). The CDs were synthesized via a one-step hydrothermal method using DL-thioctic acid and triethylenetetramine (TETA) as sources of S, N, and C. The CDs have abundant amino and carboxyl groups and were used to modify the surface of the gate electrode of SGGT as probes for detecting GSH. Remarkably, the CDs-SGGT sensor exhibited excellent selectivity and ultrahigh sensitivity to GSH, with an ultralow limit of detection (LOD) of up to 10 M. To the best of our knowledge, the sensor outperforms previously reported systems. Moreover, the CDs-SGGT sensor shows rapid detection and good stability. More importantly, the detection of GSH in artificial serum samples was successfully demonstrated.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.3c03656