Association of the rs3917647 polymorphism of the SELP gene with malnutrition in gastric cancer

   Background Malnutrition and cachexia are common syndromes in patients with gastric cancer (GC) and are associated with poor quality of life and poor disease prognosis. However, there is still a lack of molecular factors that can predict malnutrition or cachexia in cancer. Studies have shown that...

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Bibliographic Details
Published in:Supportive care in cancer 2023-12, Vol.31 (12), p.708-708, Article 708
Main Authors: Fu, Liang, Lei, Changzhen, Chen, Yingxun, Xu, Xiaoqian, Wu, Bei, Dong, Liping, Ye, Xianghong, Zheng, Lushan, Gong, Daojun
Format: Article
Language:English
Subjects:
Analysis
Animals
Cachexia - genetics
Cancer
Case-Control Studies
Chemotherapy
Development and progression
DNA
Gastric cancer
Genes
Genetic aspects
Genetic Predisposition to Disease
Genotype
Humans
Malnutrition
Malnutrition - genetics
Medicine
Medicine & Public Health
Nursing
Nursing Research
Oncology
Oncology, Experimental
Pain Medicine
Polymorphism
Polymorphism, Single Nucleotide
Prognosis
Quality of Life
Rehabilitation Medicine
Single nucleotide polymorphisms
Stomach cancer
Stomach Neoplasms - complications
Stomach Neoplasms - drug therapy
Stomach Neoplasms - genetics
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Summary:   Background Malnutrition and cachexia are common syndromes in patients with gastric cancer (GC) and are associated with poor quality of life and poor disease prognosis. However, there is still a lack of molecular factors that can predict malnutrition or cachexia in cancer. Studies have shown that among the potential contributors to the development of cancer cachexia, the level of the inflammatory response to P-selectin is regulated by single nucleotide polymorphisms (SNPs) located in the promoter region of the SELP gene. The aim of this study was to evaluate the association between the single nucleotide polymorphism (SNP)-2028 A/G of the SELP gene and malnutrition in patients receiving chemotherapy for gastric cancer (GC). Methods The study group consisted of 220 GC patients treated with chemotherapy at Jinhua Municipal Central Hospital. DNA was extracted from peripheral leukocytes of whole blood samples using an animal DNA extraction kit. DNA was amplified using a 1.1 × T3 Super PCR mix, and loci corresponding to the peaks were genotyped using SNP1 software. Results Patients carrying the A allele had a reduced risk of developing malnutrition compared to patients with the GG genotype ( P  
ISSN:0941-4355
1433-7339
DOI:10.1007/s00520-023-08161-z