Features of Interferon Status and Methods of Its Correction in the Treatment of Patients with Atypical Chronic Active Herpesvirus Infections

It is known that the imbalance of the IFN system is the cornerstone of the immunopathogenesis of atypical chronic active herpesvirus infections and is often associated not only with congenital, genetically determined defects, but also with acquired system dysregulation at different levels: receptor,...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2023-10, Vol.175 (6), p.791-793
Main Authors: Khalturina, E. O., Nesterova, I. V.
Format: Article
Language:English
Subjects:
Analysis
Biological response modifiers
Biomedical and Life Sciences
Biomedicine
Care and treatment
Cell Biology
Chronic fatigue syndrome
Congenital diseases
Development and progression
Health aspects
Herpes
Herpes viruses
Herpesvirus diseases
Immune system
Immunocompromised hosts
Immunology
Immunology and Microbiology
Immunopathogenesis
Infection
Infections
Interferon
Internal Medicine
Laboratory Medicine
Methods
Pathology
Patients
Remission (Medicine)
Viral infections
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Summary:It is known that the imbalance of the IFN system is the cornerstone of the immunopathogenesis of atypical chronic active herpesvirus infections and is often associated not only with congenital, genetically determined defects, but also with acquired system dysregulation at different levels: receptor, molecular, at the level of a nuclear transducer of signal transmission. Based on the studied features of immunopathogenesis and the revealed disturbances in the antiviral immune defense system and the IFN system in patients with atypical chronic herpes viral infections, an integration program for correcting IFN status was developed, its clinical and immunological effectiveness was evaluated. Improved effectiveness of complex rehabilitation of immunocompromised patients with atypical chronic active herpes viral infections was demonstrated.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-023-05948-2