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Features of Interferon Status and Methods of Its Correction in the Treatment of Patients with Atypical Chronic Active Herpesvirus Infections
It is known that the imbalance of the IFN system is the cornerstone of the immunopathogenesis of atypical chronic active herpesvirus infections and is often associated not only with congenital, genetically determined defects, but also with acquired system dysregulation at different levels: receptor,...
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| Published in: | Bulletin of experimental biology and medicine 2023-10, Vol.175 (6), p.791-793 |
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| container_end_page | 793 |
| container_issue | 6 |
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| container_title | Bulletin of experimental biology and medicine |
| container_volume | 175 |
| creator | Khalturina, E. O. Nesterova, I. V. |
| description | It is known that the imbalance of the IFN system is the cornerstone of the immunopathogenesis of atypical chronic active herpesvirus infections and is often associated not only with congenital, genetically determined defects, but also with acquired system dysregulation at different levels: receptor, molecular, at the level of a nuclear transducer of signal transmission. Based on the studied features of immunopathogenesis and the revealed disturbances in the antiviral immune defense system and the IFN system in patients with atypical chronic herpes viral infections, an integration program for correcting IFN status was developed, its clinical and immunological effectiveness was evaluated. Improved effectiveness of complex rehabilitation of immunocompromised patients with atypical chronic active herpes viral infections was demonstrated. |
| doi_str_mv | 10.1007/s10517-023-05948-2 |
| format | article |
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| subjects | Analysis Biological response modifiers Biomedical and Life Sciences Biomedicine Care and treatment Cell Biology Chronic fatigue syndrome Congenital diseases Development and progression Health aspects Herpes Herpes viruses Herpesvirus diseases Immune system Immunocompromised hosts Immunology Immunology and Microbiology Immunopathogenesis Infection Infections Interferon Internal Medicine Laboratory Medicine Methods Pathology Patients Remission (Medicine) Viral infections |
| title | Features of Interferon Status and Methods of Its Correction in the Treatment of Patients with Atypical Chronic Active Herpesvirus Infections |
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