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All-cause mortality and risk factors in patients with type 1 diabetes in Castilla-La Mancha, Spain. DIACAM1 2010–2020 study
Despite better treatments and care for patients with type 1 diabetes (T1DM), all-cause and cardiovascular mortality still remains higher compared to the general population. We evaluated mortality and risk factors for mortality in a representative cohort of patients with T1DM. DIACAM1 was a cross-sec...
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| Published in: | Primary care diabetes 2024-02, Vol.18 (1), p.59-64 |
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| container_end_page | 64 |
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| container_start_page | 59 |
| container_title | Primary care diabetes |
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| creator | Pinés Corrales, Pedro José Sastre Marcos, Julia López Gallardo, Gema Moreno Fernández, Jesús Herranz Antolín, Sandra Quiroga López, Iván Del Val Zaballos, Florentino González López, Javier Alfaro Martínez, José Joaquín |
| description | Despite better treatments and care for patients with type 1 diabetes (T1DM), all-cause and cardiovascular mortality still remains higher compared to the general population. We evaluated mortality and risk factors for mortality in a representative cohort of patients with T1DM.
DIACAM1 was a cross-sectional, multicenter study on adult patients (≥ 16 years old) and diabetes with at least 5 years since diabetes diagnosis conducted between 2009 and 2010. DIACAM1 2010–2020 study was a follow-up study, extension of DIACAM1, where vital status of patients was evaluated between June 2019 and June 2020.
4.03% [CI95%, 2.53–5.62) of the 1465 patients with T1DM included in the cohort of the DIACAM1 in 2010 had died. Survival was lower than in the sex- and age-matched general population in the same region. 40.7% of deaths were due to cardiovascular disease. HbA1c levels |
| doi_str_mv | 10.1016/j.pcd.2023.11.003 |
| format | article |
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DIACAM1 was a cross-sectional, multicenter study on adult patients (≥ 16 years old) and diabetes with at least 5 years since diabetes diagnosis conducted between 2009 and 2010. DIACAM1 2010–2020 study was a follow-up study, extension of DIACAM1, where vital status of patients was evaluated between June 2019 and June 2020.
4.03% [CI95%, 2.53–5.62) of the 1465 patients with T1DM included in the cohort of the DIACAM1 in 2010 had died. Survival was lower than in the sex- and age-matched general population in the same region. 40.7% of deaths were due to cardiovascular disease. HbA1c levels < 7% and triglyceride levels < 150 mg/dL were associated with lower mortality, whereas retinopathy and plasma creatinine were associated with increased mortality.
We confirmed a lower survival in people with T1DM, with cardiovascular disease being the main cause of mortality. High HbA1c, high triglycerides, retinopathy, and high creatinine are factors associated with mortality.
•4.03% of 1465 type 1 diabetes patients included in 2010 died before June 2020.•This mortality was higher than expected for the age- and sex-matched population.•The most common causes of death were cardiovascular and infectious diseases.•High HbA1c, high triglycerides, retinopathy, and high creatinine are factors associated with mortality.</description><identifier>ISSN: 1751-9918</identifier><identifier>EISSN: 1878-0210</identifier><identifier>DOI: 10.1016/j.pcd.2023.11.003</identifier><identifier>PMID: 37977987</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Creatinine ; Cross-Sectional Studies ; Diabetes mellitus ; Diabetes Mellitus, Type 1 - diagnosis ; Diabetes Mellitus, Type 1 - drug therapy ; Follow-Up Studies ; Glycated Hemoglobin ; Humans ; Mortality ; Retinal Diseases - complications ; Risk Factors ; Spain - epidemiology ; Survival ; Type 1</subject><ispartof>Primary care diabetes, 2024-02, Vol.18 (1), p.59-64</ispartof><rights>2023 Primary Care Diabetes Europe</rights><rights>Copyright © 2023 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c375t-84b7b39eddd48dcbf89eacd45c650be06de8ee4a6323857e8c1fe8d6dd5b76463</cites><orcidid>0000-0003-3853-2056 ; 0000-0002-1445-2601 ; 0000-0002-9703-1094</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37977987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pinés Corrales, Pedro José</creatorcontrib><creatorcontrib>Sastre Marcos, Julia</creatorcontrib><creatorcontrib>López Gallardo, Gema</creatorcontrib><creatorcontrib>Moreno Fernández, Jesús</creatorcontrib><creatorcontrib>Herranz Antolín, Sandra</creatorcontrib><creatorcontrib>Quiroga López, Iván</creatorcontrib><creatorcontrib>Del Val Zaballos, Florentino</creatorcontrib><creatorcontrib>González López, Javier</creatorcontrib><creatorcontrib>Alfaro Martínez, José Joaquín</creatorcontrib><creatorcontrib>In representation of the DIACAM1 2010–2020 group</creatorcontrib><title>All-cause mortality and risk factors in patients with type 1 diabetes in Castilla-La Mancha, Spain. DIACAM1 2010–2020 study</title><title>Primary care diabetes</title><addtitle>Prim Care Diabetes</addtitle><description>Despite better treatments and care for patients with type 1 diabetes (T1DM), all-cause and cardiovascular mortality still remains higher compared to the general population. We evaluated mortality and risk factors for mortality in a representative cohort of patients with T1DM.
DIACAM1 was a cross-sectional, multicenter study on adult patients (≥ 16 years old) and diabetes with at least 5 years since diabetes diagnosis conducted between 2009 and 2010. DIACAM1 2010–2020 study was a follow-up study, extension of DIACAM1, where vital status of patients was evaluated between June 2019 and June 2020.
4.03% [CI95%, 2.53–5.62) of the 1465 patients with T1DM included in the cohort of the DIACAM1 in 2010 had died. Survival was lower than in the sex- and age-matched general population in the same region. 40.7% of deaths were due to cardiovascular disease. HbA1c levels < 7% and triglyceride levels < 150 mg/dL were associated with lower mortality, whereas retinopathy and plasma creatinine were associated with increased mortality.
We confirmed a lower survival in people with T1DM, with cardiovascular disease being the main cause of mortality. High HbA1c, high triglycerides, retinopathy, and high creatinine are factors associated with mortality.
•4.03% of 1465 type 1 diabetes patients included in 2010 died before June 2020.•This mortality was higher than expected for the age- and sex-matched population.•The most common causes of death were cardiovascular and infectious diseases.•High HbA1c, high triglycerides, retinopathy, and high creatinine are factors associated with mortality.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Creatinine</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 1 - diagnosis</subject><subject>Diabetes Mellitus, Type 1 - drug therapy</subject><subject>Follow-Up Studies</subject><subject>Glycated Hemoglobin</subject><subject>Humans</subject><subject>Mortality</subject><subject>Retinal Diseases - complications</subject><subject>Risk Factors</subject><subject>Spain - epidemiology</subject><subject>Survival</subject><subject>Type 1</subject><issn>1751-9918</issn><issn>1878-0210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kMFO3DAQhi1UBJTyAL0gH3toUk-cxI56Wi2lRVrEgXK2HHsivM0mwXZAe6jUd-ANeZJ6u7THnmYO3_9r5iPkPbAcGNSf1vlkbF6wgucAOWP8gJyAFDJjBbA3aRcVZE0D8pi8DWHNWA1ciiNyzEUjRCPFCfm56PvM6Dkg3Yw-6t7FLdWDpd6FH7TTJo4-UDfQSUeHQwz0ycV7GrcTUqDW6RYj_gGWOkTX9zpbaXqtB3OvP9LbSbshpxdXi-XiGmjBgL38ek4HMxribLfvyGGn-4Bnr_OU3F1--b78lq1uvl4tF6vMcFHFTJataHmD1tpSWtN2skFtbFmZumItstqiRCx1zQsuK4HSQIfS1tZWrajLmp-SD_veyY8PM4aoNi4YTNcOOM5BFbJJriTADoU9avwYgsdOTd5ttN8qYGpnXa1Vsq521hWAStZT5vy1fm43aP8l_mpOwOc9gOnJR4deBZNsGrTOo4nKju4_9b8BjQSSWw</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Pinés Corrales, Pedro José</creator><creator>Sastre Marcos, Julia</creator><creator>López Gallardo, Gema</creator><creator>Moreno Fernández, Jesús</creator><creator>Herranz Antolín, Sandra</creator><creator>Quiroga López, Iván</creator><creator>Del Val Zaballos, Florentino</creator><creator>González López, Javier</creator><creator>Alfaro Martínez, José Joaquín</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3853-2056</orcidid><orcidid>https://orcid.org/0000-0002-1445-2601</orcidid><orcidid>https://orcid.org/0000-0002-9703-1094</orcidid></search><sort><creationdate>20240201</creationdate><title>All-cause mortality and risk factors in patients with type 1 diabetes in Castilla-La Mancha, Spain. DIACAM1 2010–2020 study</title><author>Pinés Corrales, Pedro José ; Sastre Marcos, Julia ; López Gallardo, Gema ; Moreno Fernández, Jesús ; Herranz Antolín, Sandra ; Quiroga López, Iván ; Del Val Zaballos, Florentino ; González López, Javier ; Alfaro Martínez, José Joaquín</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-84b7b39eddd48dcbf89eacd45c650be06de8ee4a6323857e8c1fe8d6dd5b76463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Creatinine</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 1 - diagnosis</topic><topic>Diabetes Mellitus, Type 1 - drug therapy</topic><topic>Follow-Up Studies</topic><topic>Glycated Hemoglobin</topic><topic>Humans</topic><topic>Mortality</topic><topic>Retinal Diseases - complications</topic><topic>Risk Factors</topic><topic>Spain - epidemiology</topic><topic>Survival</topic><topic>Type 1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pinés Corrales, Pedro José</creatorcontrib><creatorcontrib>Sastre Marcos, Julia</creatorcontrib><creatorcontrib>López Gallardo, Gema</creatorcontrib><creatorcontrib>Moreno Fernández, Jesús</creatorcontrib><creatorcontrib>Herranz Antolín, Sandra</creatorcontrib><creatorcontrib>Quiroga López, Iván</creatorcontrib><creatorcontrib>Del Val Zaballos, Florentino</creatorcontrib><creatorcontrib>González López, Javier</creatorcontrib><creatorcontrib>Alfaro Martínez, José Joaquín</creatorcontrib><creatorcontrib>In representation of the DIACAM1 2010–2020 group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Primary care diabetes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pinés Corrales, Pedro José</au><au>Sastre Marcos, Julia</au><au>López Gallardo, Gema</au><au>Moreno Fernández, Jesús</au><au>Herranz Antolín, Sandra</au><au>Quiroga López, Iván</au><au>Del Val Zaballos, Florentino</au><au>González López, Javier</au><au>Alfaro Martínez, José Joaquín</au><aucorp>In representation of the DIACAM1 2010–2020 group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>All-cause mortality and risk factors in patients with type 1 diabetes in Castilla-La Mancha, Spain. DIACAM1 2010–2020 study</atitle><jtitle>Primary care diabetes</jtitle><addtitle>Prim Care Diabetes</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>18</volume><issue>1</issue><spage>59</spage><epage>64</epage><pages>59-64</pages><issn>1751-9918</issn><eissn>1878-0210</eissn><abstract>Despite better treatments and care for patients with type 1 diabetes (T1DM), all-cause and cardiovascular mortality still remains higher compared to the general population. We evaluated mortality and risk factors for mortality in a representative cohort of patients with T1DM.
DIACAM1 was a cross-sectional, multicenter study on adult patients (≥ 16 years old) and diabetes with at least 5 years since diabetes diagnosis conducted between 2009 and 2010. DIACAM1 2010–2020 study was a follow-up study, extension of DIACAM1, where vital status of patients was evaluated between June 2019 and June 2020.
4.03% [CI95%, 2.53–5.62) of the 1465 patients with T1DM included in the cohort of the DIACAM1 in 2010 had died. Survival was lower than in the sex- and age-matched general population in the same region. 40.7% of deaths were due to cardiovascular disease. HbA1c levels < 7% and triglyceride levels < 150 mg/dL were associated with lower mortality, whereas retinopathy and plasma creatinine were associated with increased mortality.
We confirmed a lower survival in people with T1DM, with cardiovascular disease being the main cause of mortality. High HbA1c, high triglycerides, retinopathy, and high creatinine are factors associated with mortality.
•4.03% of 1465 type 1 diabetes patients included in 2010 died before June 2020.•This mortality was higher than expected for the age- and sex-matched population.•The most common causes of death were cardiovascular and infectious diseases.•High HbA1c, high triglycerides, retinopathy, and high creatinine are factors associated with mortality.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37977987</pmid><doi>10.1016/j.pcd.2023.11.003</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-3853-2056</orcidid><orcidid>https://orcid.org/0000-0002-1445-2601</orcidid><orcidid>https://orcid.org/0000-0002-9703-1094</orcidid></addata></record> |
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| ispartof | Primary care diabetes, 2024-02, Vol.18 (1), p.59-64 |
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| source | ScienceDirect Freedom Collection |
| subjects | Adolescent Adult Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology Creatinine Cross-Sectional Studies Diabetes mellitus Diabetes Mellitus, Type 1 - diagnosis Diabetes Mellitus, Type 1 - drug therapy Follow-Up Studies Glycated Hemoglobin Humans Mortality Retinal Diseases - complications Risk Factors Spain - epidemiology Survival Type 1 |
| title | All-cause mortality and risk factors in patients with type 1 diabetes in Castilla-La Mancha, Spain. DIACAM1 2010–2020 study |
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