Neurocognitive Dysfunction After Treatment for Pediatric Brain Tumors: Subtype-Specific Findings and Proposal for Brain Network-Informed Evaluations

The increasing number of long-term survivors of pediatric brain tumors requires us to incorporate the most recent knowledge derived from cognitive neuroscience into their oncological treatment. As the lesion itself, as well as each treatment, can cause specific neural damage, the long-term neurocogn...

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Bibliographic Details
Published in:Neuroscience bulletin 2023-12, Vol.39 (12), p.1873-1886
Main Authors: Sleurs, Charlotte, Fletcher, Paul, Mallucci, Conor, Avula, Shivaram, Ajithkumar, Thankamma
Format: Article
Language:English
Subjects:
Anatomy
Anesthesiology
Biomedical and Life Sciences
Biomedicine
Brain research
Brain tumors
Drug therapy
Human Physiology
Neurology
Neurosciences
Pain Medicine
Pediatrics
Review
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Summary:The increasing number of long-term survivors of pediatric brain tumors requires us to incorporate the most recent knowledge derived from cognitive neuroscience into their oncological treatment. As the lesion itself, as well as each treatment, can cause specific neural damage, the long-term neurocognitive outcomes are highly complex and challenging to assess. The number of neurocognitive studies in this population grows exponentially worldwide, motivating modern neuroscience to provide guidance in follow-up before, during and after treatment. In this review, we provide an overview of structural and functional brain connectomes and their role in the neuropsychological outcomes of specific brain tumor types. Based on this information, we propose a theoretical neuroscientific framework to apply appropriate neuropsychological and imaging follow-up for future clinical care and rehabilitation trials.
ISSN:1673-7067
1995-8218
DOI:10.1007/s12264-023-01096-9