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Choroidal Perfusion Changes After Vitrectomy for Myopic Traction Maculopathy
The choroidal vasculature supplies the outer retina and is altered in many retinal diseases, including myopic traction maculopathy (MTM). Choroid health is typically assessed by measuring the choroidal thickness; however, this method has substantial limitations. The choroidal vascularity index (CVI)...
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| Published in: | Seminars in ophthalmology 2024-05, Vol.39 (4), p.261-270 |
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| container_title | Seminars in ophthalmology |
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| creator | Quiroz-Reyes, Miguel A Quiroz-Gonzalez, Erick A Quiroz-Gonzalez, Miguel A Lima-Gomez, Virgilio |
| description | The choroidal vasculature supplies the outer retina and is altered in many retinal diseases, including myopic traction maculopathy (MTM). Choroid health is typically assessed by measuring the choroidal thickness; however, this method has substantial limitations. The choroidal vascularity index (CVI) was recently introduced to provide quantitative information on the vascular flow in the choroid. This index has been evaluated in a wide range of diseases but has not been extensively used to characterize MTM.
This study aimed to investigate the CVI across different stages of MTM and the influence of macular surgery on choroidal perfusion markers in different surgically resolved MTM stages.
Eighteen healthy myopic eyes in the control group and forty-six MTM eyes in the surgical group were evaluated using enhanced optical coherence tomography (OCT) imaging. Binarized OCT images were processed to obtain the luminal choroidal area (LCA) and stromal choroidal area (SCA), which were used to calculate CVI in the form of a percentage ratio. CVI data were collected at baseline, one and four months postoperatively, and at the final clinical visit. MTM eyes were divided into four stages based on disease severity. The choriocapillaris flow area (CFA) and central subfield thickness (CSFT) were measured along side the CVI.
No significant differences were observed between the two groups at baseline, except for visual acuity (
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| doi_str_mv | 10.1080/08820538.2023.2283029 |
| format | article |
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This study aimed to investigate the CVI across different stages of MTM and the influence of macular surgery on choroidal perfusion markers in different surgically resolved MTM stages.
Eighteen healthy myopic eyes in the control group and forty-six MTM eyes in the surgical group were evaluated using enhanced optical coherence tomography (OCT) imaging. Binarized OCT images were processed to obtain the luminal choroidal area (LCA) and stromal choroidal area (SCA), which were used to calculate CVI in the form of a percentage ratio. CVI data were collected at baseline, one and four months postoperatively, and at the final clinical visit. MTM eyes were divided into four stages based on disease severity. The choriocapillaris flow area (CFA) and central subfield thickness (CSFT) were measured along side the CVI.
No significant differences were observed between the two groups at baseline, except for visual acuity (
< 0.0001). Surgery significantly improved vision at all postoperative time points (
< 0.0001). At baseline, there were no significant differences in CVI, CFA, or CSFT scores between the control and surgical groups. However, all three measurements were lower at the final visit in the surgical group (
≤0.0001). No significant differences were found in any of the parameters among the four stages of MTM (
> 0.05). Ultimately, correlation and multivariate linear regression analyses did not reveal any significant association between CVI and visual acuity.
This study did not find significant preoperative differences in CVI between healthy myopic eyes and eyes with MTM. However, the postoperative CVI and CFA values were significantly lower than those of the control eyes. Thus, CVI may not be a good biomarker for surgical outcomes, as the correlation between CVI and visual acuity was not statistically significant.The CVI and CFA decreased after surgery, providing evidence of choroidal changes after surgical management.</description><identifier>ISSN: 0882-0538</identifier><identifier>EISSN: 1744-5205</identifier><identifier>DOI: 10.1080/08820538.2023.2283029</identifier><identifier>PMID: 37990380</identifier><language>eng</language><publisher>England</publisher><subject>Choroid - blood supply ; Humans ; Macular Degeneration ; Myopia ; Perfusion ; Retrospective Studies ; Tomography, Optical Coherence - methods ; Traction ; Vitrectomy - methods</subject><ispartof>Seminars in ophthalmology, 2024-05, Vol.39 (4), p.261-270</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c304t-1a564ab9d944da455c5cf1ac3296816e8e702b4ca6f980e6a61472ffe1b5ca933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37990380$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quiroz-Reyes, Miguel A</creatorcontrib><creatorcontrib>Quiroz-Gonzalez, Erick A</creatorcontrib><creatorcontrib>Quiroz-Gonzalez, Miguel A</creatorcontrib><creatorcontrib>Lima-Gomez, Virgilio</creatorcontrib><title>Choroidal Perfusion Changes After Vitrectomy for Myopic Traction Maculopathy</title><title>Seminars in ophthalmology</title><addtitle>Semin Ophthalmol</addtitle><description>The choroidal vasculature supplies the outer retina and is altered in many retinal diseases, including myopic traction maculopathy (MTM). Choroid health is typically assessed by measuring the choroidal thickness; however, this method has substantial limitations. The choroidal vascularity index (CVI) was recently introduced to provide quantitative information on the vascular flow in the choroid. This index has been evaluated in a wide range of diseases but has not been extensively used to characterize MTM.
This study aimed to investigate the CVI across different stages of MTM and the influence of macular surgery on choroidal perfusion markers in different surgically resolved MTM stages.
Eighteen healthy myopic eyes in the control group and forty-six MTM eyes in the surgical group were evaluated using enhanced optical coherence tomography (OCT) imaging. Binarized OCT images were processed to obtain the luminal choroidal area (LCA) and stromal choroidal area (SCA), which were used to calculate CVI in the form of a percentage ratio. CVI data were collected at baseline, one and four months postoperatively, and at the final clinical visit. MTM eyes were divided into four stages based on disease severity. The choriocapillaris flow area (CFA) and central subfield thickness (CSFT) were measured along side the CVI.
No significant differences were observed between the two groups at baseline, except for visual acuity (
< 0.0001). Surgery significantly improved vision at all postoperative time points (
< 0.0001). At baseline, there were no significant differences in CVI, CFA, or CSFT scores between the control and surgical groups. However, all three measurements were lower at the final visit in the surgical group (
≤0.0001). No significant differences were found in any of the parameters among the four stages of MTM (
> 0.05). Ultimately, correlation and multivariate linear regression analyses did not reveal any significant association between CVI and visual acuity.
This study did not find significant preoperative differences in CVI between healthy myopic eyes and eyes with MTM. However, the postoperative CVI and CFA values were significantly lower than those of the control eyes. Thus, CVI may not be a good biomarker for surgical outcomes, as the correlation between CVI and visual acuity was not statistically significant.The CVI and CFA decreased after surgery, providing evidence of choroidal changes after surgical management.</description><subject>Choroid - blood supply</subject><subject>Humans</subject><subject>Macular Degeneration</subject><subject>Myopia</subject><subject>Perfusion</subject><subject>Retrospective Studies</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Traction</subject><subject>Vitrectomy - methods</subject><issn>0882-0538</issn><issn>1744-5205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo9kD1PwzAURS0EoqXwE0AZWVL8HXusIgpIrWAorJbj2DQoqYOdDPn3JGrL9IZ77n3SAeAewSWCAj5BITBkRCwxxGSJsSAQywswRxmlKRujSzCfmHSCZuAmxh8IMcowuQYzkkkJiYBzsMn3Pviq1HXyYYPrY-UPSb7Xh28bk5XrbEi-qi5Y0_lmSJwPyXbwbWWSXdCmm-CtNn3tW93th1tw5XQd7d3pLsDn-nmXv6ab95e3fLVJDYG0S5FmnOpClpLSUlPGDDMOaUOw5AJxK2wGcUGN5k4KaLnmiGbYOYsKZrQkZAEej7tt8L-9jZ1qqmhsXeuD9X1UWEjM-eiDjSg7oib4GIN1qg1Vo8OgEFSTSHUWqSaR6iRy7D2cXvRFY8v_1tkc-QP-Xm4r</recordid><startdate>20240518</startdate><enddate>20240518</enddate><creator>Quiroz-Reyes, Miguel A</creator><creator>Quiroz-Gonzalez, Erick A</creator><creator>Quiroz-Gonzalez, Miguel A</creator><creator>Lima-Gomez, Virgilio</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240518</creationdate><title>Choroidal Perfusion Changes After Vitrectomy for Myopic Traction Maculopathy</title><author>Quiroz-Reyes, Miguel A ; Quiroz-Gonzalez, Erick A ; Quiroz-Gonzalez, Miguel A ; Lima-Gomez, Virgilio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c304t-1a564ab9d944da455c5cf1ac3296816e8e702b4ca6f980e6a61472ffe1b5ca933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Choroid - blood supply</topic><topic>Humans</topic><topic>Macular Degeneration</topic><topic>Myopia</topic><topic>Perfusion</topic><topic>Retrospective Studies</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Traction</topic><topic>Vitrectomy - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quiroz-Reyes, Miguel A</creatorcontrib><creatorcontrib>Quiroz-Gonzalez, Erick A</creatorcontrib><creatorcontrib>Quiroz-Gonzalez, Miguel A</creatorcontrib><creatorcontrib>Lima-Gomez, Virgilio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quiroz-Reyes, Miguel A</au><au>Quiroz-Gonzalez, Erick A</au><au>Quiroz-Gonzalez, Miguel A</au><au>Lima-Gomez, Virgilio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Choroidal Perfusion Changes After Vitrectomy for Myopic Traction Maculopathy</atitle><jtitle>Seminars in ophthalmology</jtitle><addtitle>Semin Ophthalmol</addtitle><date>2024-05-18</date><risdate>2024</risdate><volume>39</volume><issue>4</issue><spage>261</spage><epage>270</epage><pages>261-270</pages><issn>0882-0538</issn><eissn>1744-5205</eissn><abstract>The choroidal vasculature supplies the outer retina and is altered in many retinal diseases, including myopic traction maculopathy (MTM). Choroid health is typically assessed by measuring the choroidal thickness; however, this method has substantial limitations. The choroidal vascularity index (CVI) was recently introduced to provide quantitative information on the vascular flow in the choroid. This index has been evaluated in a wide range of diseases but has not been extensively used to characterize MTM.
This study aimed to investigate the CVI across different stages of MTM and the influence of macular surgery on choroidal perfusion markers in different surgically resolved MTM stages.
Eighteen healthy myopic eyes in the control group and forty-six MTM eyes in the surgical group were evaluated using enhanced optical coherence tomography (OCT) imaging. Binarized OCT images were processed to obtain the luminal choroidal area (LCA) and stromal choroidal area (SCA), which were used to calculate CVI in the form of a percentage ratio. CVI data were collected at baseline, one and four months postoperatively, and at the final clinical visit. MTM eyes were divided into four stages based on disease severity. The choriocapillaris flow area (CFA) and central subfield thickness (CSFT) were measured along side the CVI.
No significant differences were observed between the two groups at baseline, except for visual acuity (
< 0.0001). Surgery significantly improved vision at all postoperative time points (
< 0.0001). At baseline, there were no significant differences in CVI, CFA, or CSFT scores between the control and surgical groups. However, all three measurements were lower at the final visit in the surgical group (
≤0.0001). No significant differences were found in any of the parameters among the four stages of MTM (
> 0.05). Ultimately, correlation and multivariate linear regression analyses did not reveal any significant association between CVI and visual acuity.
This study did not find significant preoperative differences in CVI between healthy myopic eyes and eyes with MTM. However, the postoperative CVI and CFA values were significantly lower than those of the control eyes. Thus, CVI may not be a good biomarker for surgical outcomes, as the correlation between CVI and visual acuity was not statistically significant.The CVI and CFA decreased after surgery, providing evidence of choroidal changes after surgical management.</abstract><cop>England</cop><pmid>37990380</pmid><doi>10.1080/08820538.2023.2283029</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Choroid - blood supply Humans Macular Degeneration Myopia Perfusion Retrospective Studies Tomography, Optical Coherence - methods Traction Vitrectomy - methods |
| title | Choroidal Perfusion Changes After Vitrectomy for Myopic Traction Maculopathy |
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