Tumor budding is a prognostic factor in head and neck squamous cell carcinoma: A comprehensive meta-analysis and trial sequential analysis

Mortality is linked to tumor budding (TB) in certain neoplasms. TB as a relevant histopathological feature is conditioned by tumor site, a specific study on head and neck squamous cell carcinoma (HNSCC) is needed. A comprehensive meta-analysis was undertaken to investigate the relationship between T...

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Published in:Critical reviews in oncology/hematology 2024-01, Vol.193, p.104202-104202, Article 104202
Main Authors: Silva, Fábio França Vieira e, Caponio, Vito Carlo Alberto, Pérez-Sayáns, Mario, Padín-Iruegas, María Elena, Mascitti, Marco, Chamorro-Petronacci, Cintia Micaela, Suaréz-Peñaranda, José Manuel, Lorenzo-Pouso, Alejandro Ismael
Format: Article
Language:English
Subjects:
Disease-Free Survival
Head and Neck Neoplasms - diagnosis
Head and neck squamous cell carcinoma
Humans
Meta-analysis
Prognosis
Proportional Hazards Models
Squamous Cell Carcinoma of Head and Neck
Tumor budding
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Summary:Mortality is linked to tumor budding (TB) in certain neoplasms. TB as a relevant histopathological feature is conditioned by tumor site, a specific study on head and neck squamous cell carcinoma (HNSCC) is needed. A comprehensive meta-analysis was undertaken to investigate the relationship between TB and HNSCC-related outcomes. Overall 42 studies were included. Patients harboring high TB reported an Overall Survival (OS) Hazard Ratio (HR) of 2.63 (95% confidential interval (CI) 2.04–3.39; p-value
ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2023.104202