Ligands and receptors in human cytomegalovirus entry: Current therapies and new directions

•This review summarizes the ligands and receptors involved in the entry process of human cytomegalovirus.•The progress of antiviral-targeted drugs is discussed.•Trimeric and pentameric complexes play a crucial role in viral infection of cells and can serve as the core of targeted drugs.•The review p...

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Bibliographic Details
Published in:Drug discovery today 2024-01, Vol.29 (1), p.103833-103833, Article 103833
Main Authors: Zhang, Min, Wang, Xiaochen, Li, Jianshe, Peng, Fujun, Liu, Zhijun, Chen, Zhe-Sheng
Format: Article
Language:English
Subjects:
drugs
human cytomegalovirus
ligand
receptor
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Summary:•This review summarizes the ligands and receptors involved in the entry process of human cytomegalovirus.•The progress of antiviral-targeted drugs is discussed.•Trimeric and pentameric complexes play a crucial role in viral infection of cells and can serve as the core of targeted drugs.•The review provides an overview of all relevant receptors of trimeric and pentameric complexes identified in current research.•The article showcases the process of human cytomegalovirus infection in cells. The demand for human cytomegalovirus (HCMV) vaccines was first raised by a committee convened during the 1990s. A comprehensive investigation into the mechanism of viral infection supports the prioritization of developing drugs or vaccines that specifically target receptors and ligands involved in the infection process. As primary targets for neutralizing antibodies to combat HCMV, viral ligands (trimer, pentamer, and glycoprotein B) have crucial roles and exhibit substantial antiviral potential, which could be exploited for breakthroughs in antiviral research.
ISSN:1359-6446
1878-5832
DOI:10.1016/j.drudis.2023.103833