Transplant Oncology: An Emerging Discipline of Cancer Treatment

Transplant oncology is an emerging concept of cancer treatment with a promising prospective outcome. The applications of oncology, transplant medicine, and surgery are the core of transplant oncology to improve patients’ survival and quality of life. The main concept of transplant oncology is to rad...

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Bibliographic Details
Published in:Cancers 2023-11, Vol.15 (22), p.5337
Main Authors: Abdelrahim, Maen, Esmail, Abdullah, Abudayyeh, Ala, Murakami, Naoka, Victor, David, Kodali, Sudha, Cheah, Yee Lee, Simon, Caroline J, Noureddin, Mazen, Connor, Ashton, Saharia, Ashish, Moore, Linda W, Heyne, Kirk, Kaseb, Ahmed O, Gaber, A. Osama, Ghobrial, Rafik Mark
Format: Article
Language:English
Subjects:
Biomarkers
Cancer
Cancer therapies
Care and treatment
Colorectal cancer
Colorectal carcinoma
Diseases
Gastroenterology
Hepatocellular carcinoma
Immunology
Immunotherapy
Life span
Liver
Liver cancer
Liver cirrhosis
Liver diseases
Liver transplantation
Malignancy
Medical care
Metastases
Metastasis
Mortality
Oncology
Oncology, Experimental
Patients
Prognosis
Quality management
Quality of life
Quality standards
Relapse
Surgeons
Surgery
Survival
Transplantation
Transplants & implants
Tumors
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Summary:Transplant oncology is an emerging concept of cancer treatment with a promising prospective outcome. The applications of oncology, transplant medicine, and surgery are the core of transplant oncology to improve patients’ survival and quality of life. The main concept of transplant oncology is to radically cure cancer by removing the diseased organ and replacing it with a healthy one, aiming to improve the survival outcomes and quality of life of cancer patients. Subsequently, it seeks to expand the treatment options and research for hepatobiliary malignancies, which have seen significantly improved survival outcomes after the implementation of liver transplantation (LT). In the case of colorectal cancer (CRC) in the transplant setting, where the liver is the most common site of metastasis of patients who are considered to have unresectable disease, initial studies have shown improved survival for LT treatment compared to palliative therapy interventions. The indications of LT for hepatobiliary malignancies have been slowly expanded over the years beyond Milan criteria in a stepwise manner. However, the outcome improvements and overall patient survival are limited to the specifics of the setting and systematic intervention options. This review aims to illustrate the representative concepts and history of transplant oncology as an emerging discipline for the management of hepatobiliary malignancies, in addition to other emerging concepts, such as the uses of immunotherapy in a peri-transplant setting as well as the use of circulating tumor DNA (ctDNA) for surveillance post-transplantation.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15225337