Process development of inhalation powders containing simvastatin loaded liposomes using spray drying technology

The development of an inhalation powder (IP) for cancer therapy is desired to improve the therapeutic response and patient compliance. The latest studies highlighted that statins, a class of drugs used in hypercholesterolemia, can have anticancer and antiinflammatory properties. Therefore, the aim o...

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Bibliographic Details
Published in:Journal of liposome research 2024-09, Vol.34 (3), p.421-434
Main Authors: Barbălată, Cristina-Ioana, Porfire, Alina Silvia, Ambrus, Rita, Mukhtar, Mahwash, Farkas, Árpád, Tomuță, Ioan
Format: Article
Language:English
Subjects:
Administration, Inhalation
Cholesterol - chemistry
Drug Compounding - methods
Drug Liberation
Excipients - chemistry
Leucine - chemistry
Liposomes - chemistry
Mannitol - chemistry
Particle Size
Powders - chemistry
Simvastatin - administration & dosage
Simvastatin - chemistry
Spray Drying
Surface Properties
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Summary:The development of an inhalation powder (IP) for cancer therapy is desired to improve the therapeutic response and patient compliance. The latest studies highlighted that statins, a class of drugs used in hypercholesterolemia, can have anticancer and antiinflammatory properties. Therefore, the aim of the study was to develop an IP containing liposomes loaded with simvastatin using spray drying technology, as well as to investigate the influence of formulation factors on the quality attributes of the IP by means of experimental design. Results highlighted that the composition of liposomes, namely type of phospholipid and cholesterol concentration, highly influences the quality attributes of IP, and the use of optimal concentrations of excipients, i.e. D-mannitol and L-leucine, is essential to preserve the characteristics of liposomes throughout the spray drying process. The characterization of the optimal IP formulation revealed that the total percentage of released drug is higher from the IP formulation compared to the powder of active substance (53.38 vs. 42.76%) over a period of six hours, and 39.67% of dry particles have a size less than 5 µm, making them suitable for inhalation. As a conclusion, spray drying technology can be effectively used in the development and preparation of IP containing liposomes.
ISSN:0898-2104
1532-2394
DOI:10.1080/08982104.2023.2287588