An in-depth investigation of molecular interaction in zeaxanthin/corn silk glycan complexes and its positive role in hypoglycemic activity

Glycans in corn silk could interact with co-existing small molecules during its absorption, digestion, and biological process. In order to understand the exact mechanism of action of zeaxanthin, it is critical to investigate the biomolecular interactions, which were necessary to form a glycan-small...

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Bibliographic Details
Published in:Food chemistry 2024-04, Vol.438, p.137986-137986, Article 137986
Main Authors: Yang, Liu, Zi, Chengting, Li, Yanlang, Huang, Jia, Gu, Zhijia, Wang, Caiyun, Hu, Jiang-Miao, Jiang, Zhihong, Zhang, Wei
Format: Article
Language:English
Subjects:
Hypoglycemic Agents
Lipids
Polysaccharides
Silk
Zea mays - chemistry
Zeaxanthins
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Summary:Glycans in corn silk could interact with co-existing small molecules during its absorption, digestion, and biological process. In order to understand the exact mechanism of action of zeaxanthin, it is critical to investigate the biomolecular interactions, which were necessary to form a glycan-small molecule complex and yet produce the bioactive effect. So far, the in-depth study of these natural interactions has not been fully elucidated. Here, we probed that the molecular interaction between zeaxanthin (ZEA) and glycans from corn silk (CSGs) was driven by enthalpy. More importantly, it was the first time found that CSGs can bind to lipid-soluble ZEA could be binded with CSGs. It was the first report on the thermostability of insulin structure and natural glycans. This study should facilitate our understanding of the interaction between lipid soluble molecules and glycans, and provide a more comprehensive understanding of the nutrient base in food.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2023.137986