HPV co‐infections with other pathogens in cancer development: A comprehensive review

High‐risk human papillomaviruses (HR‐HPVs) cause various malignancies in the anogenital and oropharyngeal regions. About 70% of cervical and oropharyngeal cancers are caused by HPV types 16 and 18. Notably, some viruses including herpes simplex virus, Epstein–Barr virus, and human immunodeficiency v...

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Bibliographic Details
Published in:Journal of medical virology 2023-11, Vol.95 (11), p.e29236-n/a
Main Authors: Akbari, Elahe, Milani, Alireza, Seyedinkhorasani, Masoud, Bolhassani, Azam
Format: Article
Language:English
Subjects:
Anogenital
Bacteria
Cancer
Cervical cancer
Coinfection
co‐infection
Disease control
Disease transmission
Epstein-Barr virus
Epstein-Barr Virus Infections
Female
Genital tract
Herpes simplex
Herpesvirus 4, Human
HIV
HPV
HPV‐related cancers
Human immunodeficiency virus
Human papillomavirus
Humans
Malignancy
microbiome
Microbiomes
Neoplasms - complications
Papillomaviridae
Papillomavirus Infections - complications
Pathogens
Sexually transmitted diseases
STD
Vaginosis
viral pathogens
Virology
Viruses
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Summary:High‐risk human papillomaviruses (HR‐HPVs) cause various malignancies in the anogenital and oropharyngeal regions. About 70% of cervical and oropharyngeal cancers are caused by HPV types 16 and 18. Notably, some viruses including herpes simplex virus, Epstein–Barr virus, and human immunodeficiency virus along with various bacteria often interact with HPV, potentially impacting its replication, persistence, and cancer progression. Thus, HPV infection can be significantly influenced by co‐infecting agents that influence infection dynamics and disease progression. Bacterial co‐infections (e.g., Chlamydia trachomatis) along with bacterial vaginosis‐related species also interact with HPV in genital tract leading to viral persistence and disease outcomes. Co‐infections involving HPV and diverse infectious agents have significant implications for disease transmission and clinical progression. This review explores multiple facets of HPV infection encompassing the co‐infection dynamics with other pathogens, interaction with the human microbiome, and its role in disease development.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.29236