Limb Amputations in Cancer: Modern Perspectives, Outcomes, and Alternatives

Purpose of Review This review summarizes current findings regarding limb amputation within the context of cancer, especially in osteosarcomas and other bony malignancies. We seek to answer the question of how amputation is utilized in the contemporary management of cancer as well as explore current...

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Bibliographic Details
Published in:Current oncology reports 2023-12, Vol.25 (12), p.1457-1465
Main Authors: Huynh, Thien Huong N., Kuruvilla, Davis R., Nester, Matthew D., Zervoudakis, Guston, Letson, G. Douglas, Joyce, David M., Binitie, Odion T., Lazarides, Alexander L.
Format: Article
Language:English
Subjects:
Amputation
Amputation, Surgical
Artificial Limbs
Bone Neoplasms - surgery
Cancer
Humans
Malignancy
Medicine
Medicine & Public Health
Oncology
Osseointegration
Osteosarcoma
Patients
Peripheral nerves
Prosthetics
Reinnervation
Review
Topical Collection on Palliative Medicine
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Summary:Purpose of Review This review summarizes current findings regarding limb amputation within the context of cancer, especially in osteosarcomas and other bony malignancies. We seek to answer the question of how amputation is utilized in the contemporary management of cancer as well as explore current advances in limb-sparing techniques. Recent Findings The latest research on amputation has been sparse given its extensive history and application. However, new research has shown that rotationplasty, osseointegration, targeted muscle reinnervation (TMR), and regenerative peripheral nerve interfaces (RPNI) can provide patients with better functional outcomes than traditional amputation. Summary While limb-sparing surgeries are the mainstay for managing musculoskeletal malignancies, limb amputation is useful as a palliative technique or as a primary treatment modality for more complex cancers. Currently, rotationplasty and osseointegration have been valuable limb-sparing techniques with osseointegration continuing to develop in recent years. TMR and RPNI have also been of interest in the modern management of patients requiring full or partial amputations, allowing for better control over myoelectric prostheses.
ISSN:1523-3790
1534-6269
DOI:10.1007/s11912-023-01475-5