Dextran coated iron oxide nanoparticles loaded with protocatechuic acid as multifunctional therapeutic agents

Nowadays, there is a growing interest in multifunctional therapeutic agents as valuable tools to improve and expand the applicability field of traditional bioactive compounds. In this context, the synthesis and main characteristics of dextran-coated iron oxide nanoparticles (IONP-Dex) loaded with bo...

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Bibliographic Details
Published in:International journal of biological macromolecules 2024-01, Vol.256 (Pt 2), p.128314-128314, Article 128314
Main Authors: Rosca, Irina, Turin-Moleavin, Ioana-Andreea, Sarghi, Alexandra, Lungoci, Ana-Lacramioara, Varganici, Cristian-Dragos, Petrovici, Anca-Roxana, Fifere, Adrian, Pinteala, Mariana
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial activity
Dextran
Free radical scavengers
Magnetic nanoparticles
Protocatechuic acid
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Summary:Nowadays, there is a growing interest in multifunctional therapeutic agents as valuable tools to improve and expand the applicability field of traditional bioactive compounds. In this context, the synthesis and main characteristics of dextran-coated iron oxide nanoparticles (IONP-Dex) loaded with both an antioxidant, protocatechuic acid (PCA), and an antibiotic, ceftazidime (CAZ) or levofloxacin (LEV) are herein reported for the first time, with emphasis on the potentiation effect of PCA on drugs activity. All nanoparticles were characterized by transmission electron microscopy, X-ray diffraction, vibrating sample magnetometry, differential scanning calorimetry and dynamic light scattering. As evidenced by DPPH method, IONP-Dex loaded with PCA and LEV had similar antioxidant activity like those with PCA only, but higher than PCA and CAZ loaded ones. A synergy of action between PCA and each antibiotic co-loaded on IONP-Dex has been highlighted by an enhanced activity against reference bacterial strains, such as S. aureus and E. coli after 40 min of incubation. It was concluded that PCA, which is the main cause of the antioxidative properties of loaded nanoparticles, further improves the antimicrobial activity of IONP-Dex nanoparticles when was co-loaded with CAZ or LEV antibiotics. All constructs also showed a good biocompatibility with normal human dermal fibroblasts. [Display omitted]
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2023.128314