Scanning Electron Microscopy Analysis of the Intratubular Radicular Dentin Penetration of Calcium Hydroxide, Triple Antibiotic Paste, and Nitrofurantoin

The aim of this study is to assess and analyze the intratubular penetration of the intracanal medications nitrofurantoin (Nit), triple antibiotic paste (TAP), and calcium hydroxide (CH). Sixty freshly extracted single-rooted teeth were acquired and decoronated to a standard length of 15 mm. To prepa...

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Bibliographic Details
Published in:Journal of personalized medicine 2023-11, Vol.13 (11), p.1554
Main Authors: Khanvilkar, Unmesh, Pawar, Sanika, Bandekar, Siddhesh, Dhok, Vaishnavi, Arora, Suraj, Pawar, Ajinkya M, Pagnoni, Francesco, Reda, Rodolfo, Testarelli, Luca
Format: Article
Language:English
Subjects:
Antibiotics
Bacteria
Calcium hydroxide
Dentin
Electron microscopy
Endodontics
Ethylenediaminetetraacetic acid
Health aspects
Hydroxides
Infections
Investigations
Metronidazole
Microorganisms
Nitrofurantoin
Pathogens
Precision medicine
Root canal therapy
Root canals
Scanning electron microscopy
Statistical analysis
Teeth
Tetracycline
Tetracyclines
Tubules
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Summary:The aim of this study is to assess and analyze the intratubular penetration of the intracanal medications nitrofurantoin (Nit), triple antibiotic paste (TAP), and calcium hydroxide (CH). Sixty freshly extracted single-rooted teeth were acquired and decoronated to a standard length of 15 mm. To prepare specimens up to size F3, rotary ProTaper instrumentation was employed. The prepared teeth were divided into three groups, each of which received one of the tested intracanal medicaments: Group I (calcium hydroxide), Group II (triple antibiotic paste), and Group III (nitrofurantoin). Using a size #30 Lentulo spiral, a freshly prepared therapeutic paste was placed into the canals, and the intracanal medicaments were allowed to set in the incubator at 100% humidity. The samples were subsequently sliced perpendicularly to their long axis using a precision saw and assessed under a scanning electron microscope to assess the depth of penetration of intracanal medicaments at the coronal, middle, and apical portions of the root canal dentin. The data were analyzed using one-way ANOVA and Tukey’s post hoc test. The statistical analysis revealed a significant difference between the experimental groups in the quantity and depth of sealer penetration (p < 0.05). In particular, as compared to the Nit group, both the CH and TAP groups had significantly smaller penetration areas (p < 0.05). In conclusion, this ongoing investigation indicates that nitrofurantoin penetrated dentinal tubules better than calcium hydroxide or triple antibiotic paste.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm13111554