Gut Microbiome–Estrobolome Profile in Reproductive-Age Women with Endometriosis

Microbiota is associated with our bodily functions and microenvironment. A healthy, balanced gut microbiome not only helps maintain mucosal integrity, prevents translocation of bacterial content, and contributes to immune status, but also associates with estrogen metabolism. Gut dysbiosis and estrob...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-11, Vol.24 (22), p.16301
Main Authors: Pai, Angel Hsin-Yu, Wang, Yi-Wen, Lu, Pei-Chen, Wu, Hsien-Ming, Xu, Jia-Ling, Huang, Hong-Yuan
Format: Article
Language:English
Subjects:
Bacteria
Digestive system
Discriminant analysis
Endometriosis
Enzymes
Estrogen
Estrogens
Ethical aspects
Ethnicity
Feces
Homeostasis
Infertility
Instrument industry
Medical research
Medicine, Experimental
Metabolism
Metabolites
Microbiota
Microbiota (Symbiotic organisms)
Urine
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Summary:Microbiota is associated with our bodily functions and microenvironment. A healthy, balanced gut microbiome not only helps maintain mucosal integrity, prevents translocation of bacterial content, and contributes to immune status, but also associates with estrogen metabolism. Gut dysbiosis and estrobolome dysfunction have hence been linked to certain estrogen-dependent diseases, including endometriosis. While prior studies on microbiomes and endometriosis have shown conflicting results, most of the observed microbial differences are seen in the genital tract. This case-control study of reproductive-age women utilizes their fecal and urine samples for enzymatic, microbial, and metabolic studies to explore if patients with endometriosis have distinguishable gut microbiota or altered estrogen metabolism. While gut β-glucuronidase activities, microbial diversity, and abundance did not vary significantly between patients with or without endometriosis, fecal samples of patients with endometriosis were more enriched by the Erysipelotrichia class and had higher folds of four estrogen/estrogen metabolites. Further studies are needed to elucidate what these results imply and whether there indeed is an association or causation between gut microbiota and endometriosis.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms242216301