The Role of the Tumor Microenvironment in Triple-Positive Breast Cancer Progression and Therapeutic Resistance

Breast cancer (BRCA) is a highly heterogeneous systemic disease. It is ranked first globally in the incidence of new cancer cases and has emerged as the primary cause of cancer-related death among females. Among the distinct subtypes of BRCA, triple-positive breast cancer (TPBC) has been associated...

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Bibliographic Details
Published in:Cancers 2023-11, Vol.15 (22), p.5493
Main Authors: Pu, Qian, Gao, Haidong
Format: Article
Language:English
Subjects:
Angiogenesis
Bone marrow
Breast cancer
Cancer
Cancer therapies
Carcinogenesis
Cell growth
Chemotherapy
Cytokines
Development and progression
Drug resistance
Endocrine therapy
Estrogens
Fibroblasts
Growth factors
Health aspects
Hormones
Invasiveness
Kinases
Medical prognosis
Metabolism
Metastases
Metastasis
Oncology, Experimental
Patients
Stem cells
Trastuzumab
Tumor cells
Tumor microenvironment
Tumorigenesis
Tumors
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Summary:Breast cancer (BRCA) is a highly heterogeneous systemic disease. It is ranked first globally in the incidence of new cancer cases and has emerged as the primary cause of cancer-related death among females. Among the distinct subtypes of BRCA, triple-positive breast cancer (TPBC) has been associated with increased metastasis and invasiveness, exhibiting greater resistance to endocrine therapy involving trastuzumab. It is now understood that invasion, metastasis, and treatment resistance associated with BRCA progression are not exclusively due to breast tumor cells but are from the intricate interplay between BRCA and its tumor microenvironment (TME). Accordingly, understanding the pathogenesis and evolution of the TPBC microenvironment demands a comprehensive approach. Moreover, addressing BRCA treatment necessitates a holistic consideration of the TME, bearing significant implications for identifying novel targets for anticancer interventions. This review expounds on the relationship between critical cellular components and factors in the TPBC microenvironment and the inception, advancement, and therapeutic resistance of breast cancer to provide perspectives on the latest research on TPBC.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15225493