Electrospun PCL Wires Loaded with Vancomycin on Zirconium Substrate

The current study presents research about electrodeposition in relation to electrospinning PCL wires on a Zr substrate and loading the coating with vancomycin. The structural composition of the coatings was investigated via FT-IR analysis. The morphology evaluated using scanning electron microscopy...

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Bibliographic Details
Published in:Materials 2023-11, Vol.16 (22), p.7237
Main Authors: Radu (Dusman), Ramona-Daniela, Voicu, Manuela Elena, Prodana, Mariana, Demetrescu, Ioana, Anuta, Valentina, Draganescu, Doina
Format: Article
Language:English
Subjects:
Analysis
Antibiotics
Bacterial infections
Biocompatibility
Biomedical materials
Body fluids
Coatings
Composition
Contact angle
Corrosion and anti-corrosives
Corrosion resistance
Drug delivery systems
Electrochemical reactions
Electrodes
Electrospinning
Infrared analysis
Investigations
Mechanical properties
Methicillin
Nanowires
Polymers
Scanning electron microscopy
Staphylococcus infections
Substrates
Tissue engineering
Titanium alloys
Transplants & implants
Vancomycin
Wettability
Zirconium
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Summary:The current study presents research about electrodeposition in relation to electrospinning PCL wires on a Zr substrate and loading the coating with vancomycin. The structural composition of the coatings was investigated via FT-IR analysis. The morphology evaluated using scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy, for the composition (SEM-EDS), evidenced the presence of the polymer wires, with and without drug vancomycin loading. The wettability of the coatings was evaluated from the hydrophobic–hydrophilic point of view, and the characterization was completed with mechanical and electrochemical tests. All the electrochemical tests performed in simulated body fluid highlighted that PCL represents a barrier against corrosion processes. The quantitative method to evaluate the loading efficiency shows that almost 80% of the total loaded vancomycin is released within 144 h; after the initial burst at 24 h, a steady release of vancomycin is observed over 7 days. A kinetic model of the drug release was also constructed.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma16227237