Pseudocarcinomatous Hyperplasia of the Nose and Necrotic Tracheitis Associated with Acute Myeloid Leukemia

A 29-year-old woman who had been diagnosed with acute myeloid leukemia presented with persistent grade-4 febrile neutropenia (FN) after initial chemotherapy with idarubicin and cytarabine. Despite intensive treatment, FN persisted. Subsequently, her nose became reddish and swollen, obstructing the n...

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Bibliographic Details
Published in:Internal Medicine 2024/07/15, Vol.63(14), pp.2063-2067
Main Authors: Kajikawa, Shigehisa, Murakami, Satsuki, Takami, Akiyoshi, Satou, Akira, Tsuzuki, Toyonori, Ogisu, Tomoyuki, Yonezawa, Toshiyuki, Tanaka, Hiroyuki, Kubo, Akihito, Ito, Satoru
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Adult
Biopsy
bronchoscopy
Chemotherapy
Computed tomography
Cytarabine
Cytarabine - administration & dosage
Cytarabine - therapeutic use
Female
Humans
Hyperplasia
Leukemia, Myeloid, Acute - complications
Leukemia, Myeloid, Acute - diagnosis
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - pathology
Leukopenia
Necrosis
necrotizing tracheitis
Neutropenia
Nose
Nose - pathology
pseudocarcinomatous hyperplasia
Tracheitis
Tracheitis - complications
Tracheitis - diagnosis
Tracheitis - drug therapy
Tracheitis - etiology
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Description
Summary:A 29-year-old woman who had been diagnosed with acute myeloid leukemia presented with persistent grade-4 febrile neutropenia (FN) after initial chemotherapy with idarubicin and cytarabine. Despite intensive treatment, FN persisted. Subsequently, her nose became reddish and swollen, obstructing the nasal cavities. Computed tomography revealed swelling of the nostrils and an irregular tracheal surface. Debridement of the nasal lesion and a bronchoscopic biopsy of the tracheal lesion were also performed. A histopathological examination revealed pseudocarcinomatous hyperplasia (PCH) of the nose and necrotizing tracheitis. Both nasal PCH and necrotizing tracheitis ameliorated when the patient recovered from leukocytopenia.
ISSN:0918-2918
1349-7235
1349-7235
DOI:10.2169/internalmedicine.2625-23