Shark fish oil prevents scopolamine-induced memory impairment in an experimental model

• Published in: Metabolic brain disease 2024, Vol.39 (1), p.15-27
• Main Authors: Naeem, Sadaf, Ali, Liaquat, Jaffar, Nazish, Khan, Saira Saeed, Shafiq, Yousra, Suri, Sadia, Tahir, Anosh
• Format: Article
• Language: English
• Subjects: Acetylcholine - pharmacology; Amnesia; Animals; Avoidance; Biochemistry; Biomedical and Life Sciences; Biomedicine; Brain; Distortion; Donepezil; Fish oils; Fish Oils - pharmacology; Hippocampus; Hippocampus - metabolism; Histology; Impairment; Inflammation; Male; Maze Learning; Memory; Memory Disorders - chemically induced; Memory Disorders - drug therapy; Memory Disorders - prevention & control; Memory tasks; Metabolic Diseases; Mice; Models, Theoretical; Monoamines; Neurology; Neuroprotection; Neurosciences; Oncology; Original Article; Polyunsaturated fatty acids; Rats; Scopolamine; Sharks; Spatial analysis; Spatial memory
• ISSN: 1573-7365; 0885-7490; 1573-7365
• DOI: 10.1007/s11011-023-01320-5

Fish oil has been known for its antioxidant, cardioprotective, anti-inflammatory, and neuroprotective characteristics due to the presence of polyunsaturated fatty acids (PUFAs) that are essential for optimal brain function and mental health. The present study investigated the effect of Carcharhinus Bleekeri (Shark Fish) oil on learning and memory functions in scopolamine-induced amnesia in rats. Locomotor and memory-enhancing activity in scopolamine-induced amnesic rats was investigated by assessing the open field and passive avoidance paradigm. Forty male Albino mice were divided into 4 equal groups ( n  = 10) as bellow: 1 – control (received 0.9% saline), 2 – SCOP (received scopolamine 2 mg/kg for 21 days), 3 – SCOP + SFO (received scopolamine and fish oil 5 mg/kg/ day for 21 days), 4 – SCOP + Donepezil groups (received 3 mg/kg/day for 21 days). SFO produced significant (P