Monocyte to high-density lipoprotein ratio as a novel-potential biomarker for predicting prognosis of Bell’s palsy

• Published in: European archives of oto-rhino-laryngology 2024-05, Vol.281 (5), p.2293-2301
• Main Authors: Jin, Fanyuan, Yu, Erhui, Chen, Junkang, Zhou, Wenhui, Cai, Huafeng, Hu, Jinhua, Xuan, Lihua
• Format: Article
• Language: English
• Subjects: Head and Neck Surgery; Medicine; Medicine & Public Health; Neurosurgery; Otology; Otorhinolaryngology
• ISSN: 0937-4477; 1434-4726
• DOI: 10.1007/s00405-023-08340-y

Objectives In several disorders, the monocyte to high-density lipoprotein ratio (MHR) has been considered a biomarker of systemic inflammation and oxidative stress. However, its role in Bell’s palsy (BP) remains unclear. This study investigates the relationship between elevated MHR and poor recovery in BP patients. Methods The clinical data of 729 BP patients were analyzed retrospectively. The House-Brackmann Facial Nerve Grading System (H-B) was utilized to assess the severity of facial motor dysfunction during admission and the follow-up period after discharge. According to the 6 months follow-up data, H-B grades 1–2 were classified as recovered ( n  = 557), and H-B grades 3–6 as unrecovered ( n  = 172). The patients were split into MHR ≤ 0.26 ( n  = 361) and MHR > 0.26 ( n  = 368) groups based on the median MHR to further analyze the connection between different MHRs and prognosis. Results The level of MHR was substantially greater in the unrecovered group of BP patients than in the restored group (medians[interquartile range], 0.32[0.20, 0.49] vs 0.24[0.11, 0.39], P