Molecular pathology as basis for timely cancer diagnosis and therapy

Precision and personalized therapeutics have witnessed significant advancements in technology, revolutionizing the capabilities of laboratories to generate vast amounts of genetic data. Coupled with computational resources for analysis and interpretation, and integrated with various other types of d...

Full description

Saved in:
Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2024-02, Vol.484 (2), p.155-168
Main Authors: Mackinnon, A. Craig, Chandrashekar, Darshan Shimoga, Suster, David I.
Format: Article
Language:English
Subjects:
Cancer
Cancer therapies
Copy number
Customization
Decisions
Diagnosis
Epigenetics
Gene expression
Gene sequencing
Genomes
Health services
Medical diagnosis
Medicine
Medicine & Public Health
Next-generation sequencing
Pathology
Precision medicine
Review and Perspectives
Therapeutic targets
Whole genome sequencing
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Precision and personalized therapeutics have witnessed significant advancements in technology, revolutionizing the capabilities of laboratories to generate vast amounts of genetic data. Coupled with computational resources for analysis and interpretation, and integrated with various other types of data, including genomic data, electronic medical health (EMH) data, and clinical knowledge, these advancements support optimized health decisions. Among these technologies, next-generation sequencing (NGS) stands out as a transformative tool in the field of cancer treatment, playing a crucial role in precision oncology. NGS-based workflows are employed across a range of applications, including gene panels, exome sequencing, and whole-genome sequencing, supporting comprehensive analysis of the entire cancer genome, including mutations, copy number variations, gene expression profiles, and epigenetic modifications. By utilizing the power of NGS, these workflows contribute to enhancing our understanding of disease mechanisms, diagnosis confirmation, identifying therapeutic targets, and guiding personalized treatment decisions. This manuscript explores the diverse applications of NGS in cancer treatment, highlighting its significance in guiding diagnosis and treatment decisions, identifying therapeutic targets, monitoring disease progression, and improving patient outcomes.
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-023-03707-2