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Lymphoid interstitial pneumonia in a patient with systemic lupus erythematosus: Case report and literature review

Lymphoid interstitial pneumonia (LIP) is a rare form of interstitial pulmonary disease, which has been described in association with a wide range of autoimmune disorders. Although the association of this entity with Sjogren’s syndrome is well known, only a few cases are reported in relation to syste...

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Published in:Lupus 2024-01, Vol.33 (1), p.83-87
Main Authors: Dans Vilán, Laura, Ríos Fernández, Raquel, Fernández Ontiveros, Sergio, Suárez Robles, Miguel, Caba Molina, Mercedes, García Morales, Marta, De la Hera, Francisco Javier, Ortego Centeno, Norberto, Callejas Rubio, Jose Luis
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container_title Lupus
container_volume 33
creator Dans Vilán, Laura
Ríos Fernández, Raquel
Fernández Ontiveros, Sergio
Suárez Robles, Miguel
Caba Molina, Mercedes
García Morales, Marta
De la Hera, Francisco Javier
Ortego Centeno, Norberto
Callejas Rubio, Jose Luis
description Lymphoid interstitial pneumonia (LIP) is a rare form of interstitial pulmonary disease, which has been described in association with a wide range of autoimmune disorders. Although the association of this entity with Sjogren’s syndrome is well known, only a few cases are reported in relation to systemic lupus erythematosus (SLE). The aim of this paper is to review the cases reported in literature to date, as well as to describe the characteristics of these patients including the new case presented herein. We will be focusing on the case of a 36-year-old female patient diagnosed with SLE on hydroxychloroquine treatment who develops pleuritic chest pain and progressive dyspnea after 3 years of follow-up. The chest CT scan showed pleural thickening and both multiple and bilateral micronodules. A lung biopsy was also performed, revealing an infiltration of lymphocytes, plasma cells, and histiocytes in the alveolar septa suggestive of LIP. After conducting a review of the literature, we identified seven other cases describing SLE in association with LIP. The majority of them were young women, and LIP tends to appear early in the course of the disease, even as a form of initial presentation in some cases. Symptoms included cough, dyspnea, and pleuritic pain, with the exception of one case which was asymptomatic. It is noteworthy that half of the patients were positive for anti-SSA/anti-SSB autoantibodies, and some of them also met criteria for Sjogren’s syndrome. Treatment with steroids and other immunosuppressive agents improved symptoms in all of them.
doi_str_mv 10.1177/09612033231218957
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identifier ISSN: 0961-2033
ispartof Lupus, 2024-01, Vol.33 (1), p.83-87
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1477-0962
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subjects Adult
Alveoli
Autoantibodies
Autoimmune diseases
Biopsy
Chest
Computed tomography
Cough
Dyspnea
Dyspnea - etiology
Female
Humans
Hydroxychloroquine
Immunosuppressive agents
Literature reviews
Lung diseases
Lung Diseases, Interstitial - diagnosis
Lung Diseases, Interstitial - drug therapy
Lung Diseases, Interstitial - etiology
Lupus
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - drug therapy
Lymphocytes
Pain
Plasma cells
Pleurisy - complications
Pneumonia
Respiration
Sjogren's syndrome
Sjogren's Syndrome - complications
Sjogren's Syndrome - diagnosis
Sjogren's Syndrome - drug therapy
Steroid hormones
Systemic lupus erythematosus
title Lymphoid interstitial pneumonia in a patient with systemic lupus erythematosus: Case report and literature review
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